del(13q) in non-Hodgkins lymphoma

1999-11-01   Antonio Cuneo 

1.Hematology Section, Dept. Of Biomedical Sciences, University of Ferrara, 44100 Ferrara Italy

Clinics and Pathology



Phenotype stem cell origin

peripheral B-cells at different stages of differentiation
  • pre germinal centre: small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL)
  • post-germinal centre: marginal zone B-cell lymphoma (MZBCL) follicle centre cell lymphoma (FCCL), diffuse large cell lymphoma (DLCL)
  • Epidemiology

  • SLL: 5-10% of all NHL diagnosed by surgical biospy
  • MCL: 5-10% of all NHL in western countries
  • MZBCL: 0-15% of NHL, including the extra-nodal form the nodal and the splenic form
  • FCCL: 30-40% of NHL
  • DLCL: 30-40% of NHL
  • Clinics

  • SLL: low-grade histology, usually running an indolent course; survival largely dependent on clinical stage at presentation
  • MCL: intermediate-grade histology, poor response to therapy, median survival 3-4 years
  • MZBCL: low-grade histology, indolent disease, median survival >5 years
  • FCCL: low-grade histology, indolent disease, median survival > 5 years
  • DLCL: high grade histology, aggressive disease, survival influenced by age, stage at presentation, performance status
  • Prognosis

    the significance of 13q- is uncertain because of heterogeneity of patients population and histology; a low CR rate was described but it is not clear whether this depends on its close association with MCL


    Atlas Image

    Additional anomalies

    with the notable exception of SLL/CLL the 13q deletion is not found as an isolated change in NHL; it was reported as a stemline-associated anomaly in most cases having complex karyotypes, suggesting that it may represent a relatively early event in the cytogenetic history of NHL; the association with other anomalies reflects the incidence of the 13q- chromosome in distinct histologic subsets: thus it was frequently found in karyotypes presenting the t(11;14)(q13;q32); many patients with the inv(14)(q11q32), associated with T-cell lymphoid neoplasias, were found to carry a 13q- chromosome

    Genes Involved and Proteins

    involved loci: the few characterized cases showed a deletion of the D13S319 marker, located between the Rb locus and the D13S25 marker; FISH studies were performed using probes targeting the Rb locus or the loci comprised between Rb and the D13S25 marker


    Pubmed IDLast YearTitleAuthors
    94547691998Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia.Corcoran MM et al
    10406898199913q14 deletion in non-Hodgkin's lymphoma: correlation with clinicopathologic features.Cuneo A et al
    75793601995Cytogenetic evolution patterns in non-Hodgkin's lymphoma.Johansson B et al
    94142891998Molecular delineation of 13q deletion boundaries in 20 patients with myeloid malignancies.La Starza R et al
    7655020199513q deletions in lymphoid malignancies.Liu Y et al
    95836871998Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma.Stilgenbauer S et al
    74927841995Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities.Tricot G et al
    103748851999Frequent chromosome arm 13q deletion in aggressive non-Hodgkin's lymphoma.Wada M et al



    the chromosome 13q deletion is a relatively common finding in chronic myeloproliferative disorders and lymphoid neoplasias, including B-cell chronic lymphocytic leukemia (CLL), non-Hodgkins lymphoma (NHL) and multiple myeloma (MM). Whereas the commonly deleted region comprise a 100-kb gene-rich segment at the 13q14 chromosome band in CLL, the commonly deleted segment in NHL was not characterized in detail.
    Atlas Image
    del(13)(q14q21) in NHL (G-banding) - Antonio Cuneo; the vertical bar indicates the missing chromosome segment (left); del(13)(q14q33) R- banding (right) - Editor


    Antonio Cuneo

    del(13q) in non-Hodgkins lymphoma

    Atlas Genet Cytogenet Oncol Haematol. 1999-11-01

    Online version: