del(7q) in non-Hodgkins lymphoma (NHL)

2001-01-01   Gianluigi Castoldi  , Antonio Cuneo  

1.Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

Clinics and Pathology

Disease

the frequency of 7q deletions in unseletced NHL is less than 5%; an association with splenic marginal zone B-cell lymphomas (MZBCL) was established, with a 20-30% incidence; sensitive molecular genetic studies found a 40% incidence in splenic MZBCL, as against a 7% incidence in other forms of NHL

Prognosis

there may be an association of 7q- with tumor progression or transformation into a high-grade MZBCL

Cytogenetics

Cytogenetics morphological

7q deletions or unbalanced 7q translocations in NHL usually involve a relatively large segment, usually centered around the 7q22-q32 region

Cytogenetics molecular

conventional G- or R-banded preparations detect the majority of cases; however some patients with submicroscopic deletion were detected by FISH or loss-of-heterozigosity studies

Genes Involved and Proteins

Note
the involved gene(s) are unknown; the minimal region of deletion in MZBCL carrying a 7q- chromosome was narrowed down to a 5cM segment defined by the D7S685 and D7S514 markers; homozygous deletion of the D7S685 was reported, suggesting that a tumor suppressor gene relevant to lymphomagenesis may be located in this region; a recurrent 7q21 translocation involving a small 3.6 Kb segment upstream of the cyclin-dependent kinase 6 gene ( CDK6), with resultant CDK6 overexpression, was described

Article Bibliography

Pubmed IDLast YearTitleAuthors
105972251999Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations.Corcoran MM et al
111465732001Molecular cytogenetic characterization of marginal zone B-cell lymphoma: correlation with clinicopathologic findings in 14 cases.Cuneo A et al
1032961019997q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma.Mateo M et al
81362701993Cytogenetic studies in splenic lymphoma with villous lymphocytes.Oscier DG et al

Summary

Atlas Image
del(7q) in non-Hodgkins lymphoma (NHL) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Citation

Gianluigi Castoldi ; Antonio Cuneo

del(7q) in non-Hodgkins lymphoma (NHL)

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2082/del(7q)-in-non-hodgkins-lymphoma-(nhl)