t(1;21)(q12;q22) RUNX1/?

2009-06-01   Yongquan Xue , Jean-Loup Huret 

1.Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, PR China (YX); Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH)

Clinics and Pathology

Disease

Epidemiology

Only one case reported in the literature till now, a 53-year-old female patient (Dai et al., 2007).

Prognosis

The patient was still in remission 26 months after diagnosis.

Genes Involved and Proteins

Note
The gene partner in chromosome 1q12 is unknown.
Gene name
RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location
21q22.12
Dna rna description
Transcription from telomere to centromere.
Protein description
Contains the RUNT binding domain at 5 portion and the transactivation domain at 3 portion. Forms heterodimers; widely expressed; nuclear localization; a transcription factor and critical regulator of hematopoietic-cell development.

Bibliography

Pubmed IDLast YearTitleAuthors
178546662007Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia.Dai H et al

Citation

Yongquan Xue ; Jean-Loup Huret

t(1;21)(q12;q22) RUNX1/?

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/haematological/2135/t(1;21)(q12;q22)

External Links