t(12;15)(p13;q25) NTRK3/ETV6

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

NTRK3

Location

15q25.3

Gene name

ETV6

Location

12p13.2

Highly cited references

Pubmed IDYearTitleCitations
267849372016NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States.59
270932992016Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101.34
214019662011Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia.33
295556612018Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression.8
344903452021Evaluation of NTRK Gene Fusion by Five Different Platforms in Triple-Negative Breast Carcinoma.1
358342232022Congenital Infantile Fibrosarcoma Involving Pelvic Wall and Thigh Soft Tissues and Placenta, Presenting with Coagulopathy.0

Bibliography

Pubmed IDLast YearTitleAuthors
255005442015The landscape and therapeutic relevance of cancer-associated transcript fusions.Yoshihara K et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(12;15)(p13;q25) NTRK3/ETV6

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/101479/t(12;15)(p13;q25)-ntrk3-etv6