t(1;5)(q23;q35) SQSTM1/NTRK1

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

SQSTM1

Location

5q35.3

Gene name

NTRK1

Location

1q23.1

Highly cited references

Pubmed IDYearTitleCitations
327374492020Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization.67
281836972017Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).42
324574072020Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC).33
339237282021NTRK Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis.32
390141822024Larotrectinib efficacy for liver metastases in papillary thyroid carcinoma patient harboring SQSTM1-NTRK1 fusion.24
388357422024Difficulties of Preoperative Diagnosis of Cribriform Morular Thyroid Carcinoma.22
399119152025Metastatic SQSTM1-NTRK1 fused non-small-cell lung cancer treated with larotrectinib and stereotactic radiosurgery resulting in durable complete response: a case report.16
265653812015Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer.13
383763152023A novel EML4-NTRK3 fusion in lung adenocarcinoma with dramatic response to entrectinib.0
351189952022An impressive response with larotrectinib in a patient with a papillary thyroid carcinoma harboring an SQSTM1-NTRK1 fusion.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
252044152014The landscape of kinase fusions in cancer.Stransky N et al
254171142014Integrated genomic characterization of papillary thyroid carcinoma.
255005442015The landscape and therapeutic relevance of cancer-associated transcript fusions.Yoshihara K et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(1;5)(q23;q35) SQSTM1/NTRK1

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/104436/t(1;5)(q23;q35)-sqstm1-ntrk1