t(1;6)(p34;p21) MEAF6/PHF1

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

1p34.3

Gene name

Location

6p21.32

Highly cited references

Pubmed IDYearTitleCitations
235803822013Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation.43
242854342014Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors--molecular characterization shows genetic overlap with endometrial stromal sarcoma.42
239599732014Identification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma.42
227617692012Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma.32
292759292018Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations.28
245302302014MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.24
264298732015Genomic landscape of endometrial stromal sarcoma of uterus.10
267323022016Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.8
319326802020PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells.4
328205702020Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule.2

Bibliography

Pubmed IDLast YearTitleAuthors
227617692012Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma.Panagopoulos I et al
245302302014MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.Micci F et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(1;6)(p34;p21) MEAF6/PHF1

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/104461/t(1;6)(p34;p21)-meaf6-phf1