t(2;15)(p21;q25) EML4/NTRK3

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

2p21

Gene name

Location

15q25.3

Highly cited references

Pubmed IDYearTitleCitations
290995032018Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy.34
286835892018Infantile NTRK-associated Mesenchymal Tumors.26
327374492020Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization.24
288770622018Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma.22
324574072020Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC).21
308772732019Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms.18
315671892020Colonic Adenocarcinomas Harboring NTRK Fusion Genes: A Clinicopathologic and Molecular Genetic Study of 16 Cases and Review of the Literature.16
306685252019Targetable gene fusions identified in radioactive iodine refractory advanced thyroid carcinoma.13
271485712015Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma.12
339237282021NTRK Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis.10
301754682018A novel case of an aggressive superficial spindle cell sarcoma in an adult resembling fibrosarcomatous dermatofibrosarcoma protuberans and harboring an EML4-NTRK3 fusion.7
344025292021NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions.3
355729732022EML4-NTRK3 Fusion Cervical Sarcoma: A Case Report and Literature Review.1
345839472021Molecular characterisation of pancreatic ductal adenocarcinoma with NTRK fusions and review of the literature.1
359775942022Pan-tropomyosin receptor kinase immunohistochemistry is a feasible routine screening strategy for NTRK fusions in mismatch repair-deficient colorectal carcinomas.0

Bibliography

Pubmed IDLast YearTitleAuthors
285122422017A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer.Kloosterman WP et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;15)(p21;q25) EML4/NTRK3

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105038/t(2;15)(p21;q25)-eml4-ntrk3