t(2;2)(p13;p23) DCTN1/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

DCTN1

Location

2p13.1

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
289705582017Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches.41
294375952018Integrated molecular profiling of juvenile myelomonocytic leukemia.28
258134042015Novel ALK fusion partners in lung cancer.28
260628232015STUMP un"stumped": anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusion.28
278741932017ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma.23
298726932017ALKG1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor.12
281675722017An Oncogenic ALK Fusion and an RRAS Mutation in KRAS Mutation-Negative Pancreatic Ductal Adenocarcinoma.8
347271722022ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.5
349642762022Effectiveness of alectinib and osimertinib in a brain metastasized lung adenocarcinoma patient with concurrent EGFR mutations and DCTN1-ALK fusion.2
340198662021Identification of novel ALK fusions using DNA/RNA sequencing in immunohistochemistry / RT-PCR discordant NSCLC patients.2
318806822020Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old.2
352121542022Response to ALK-TKIs in a lung adenocarcinoma patient harboring dual DCTN1-ALK and ALK-CLIP4 rearrangements.1
340143672021DCTN1-ALK gene fusion in inflammatory myofibroblastic tumor (IMT) of the CNS.1
352291872022Spindle cell/sclerosing rhabdomyosarcoma with DCTN1::ALK fusion: broadening the molecular spectrum with potential therapeutic implications.0
332170022021Spindle cell variant of epithelioid cell histiocytoma (spindle cell histiocytoma) with ALK gene fusions: Cases series and review of the literature.0
340265992021Resistance Profile of Osimertinib in Pre-treated Patients With EGFR T790M-Mutated Non-small Cell Lung Cancer.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
258134042015Novel ALK fusion partners in lung cancer.Iyevleva AG et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;2)(p13;p23) DCTN1/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105145/js/js/_common.js