t(2;2)(p23;q35) FN1/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

FN1

Location

2q35

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
371530352023Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report.25
392801262024Urachal inflammatory myofibroblastic tumor with FN1: : ALK fusion: A case report and literature review.19
342485452021Uterine Leiomyosarcoma with FN1-Anaplastic Lymphoma Kinase Fusion Responsive to Alectinib and Lorlatinib.15
274693272016Recurrent fusion of the genes FN1 and ALK in gastrointestinal leiomyomas.0
329082532021Pseudosarcomatous myofibroblastic proliferations of the urinary bladder are neoplasms characterized by recurrent FN1-ALK fusions.0
256829422015FN1: a novel fusion partner of ALK in an inflammatory myofibroblastic tumor.0
366358922023Pediatric inflammatory myofibroblastic tumor of the bladder with ALK-FN1 fusion successfully treated by alectinib.0
330073142020Inflammatory Myofibroblastic Tumor of the Bladder With FN1-ALK Gene Fusion: Different Response to ALK Inhibition.0
284900452017Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1.0
225702542012Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
274693272016Recurrent fusion of the genes FN1 and ALK in gastrointestinal leiomyomas.Panagopoulos I et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;2)(p23;q35) FN1/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105219/t(2;2)(p23;q35)-fn1-alk