t(2;5)(p23;q35) SQSTM1/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

SQSTM1

Location

5q35.3

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
367548392023Inflammatory myofibroblastic tumor of the mesentery with a SQSTM1::ALK fusion responding to alectinib.33
398103982025Assessment of Exhaled Breath Condensate for ALK, RET, ROS1, and NTRK1 Fusion Transcript Detection in NSCLC: Comparison With Tissue and Liquid Biopsy Samples.33
211349802011Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma.24
297476762018Epithelioid cell histiocytoma with SQSTM1-ALK fusion: a case report.19
396513812024Partial Response to Treatment with ALK Inhibitor in a Patient With SQSTM1-ALK Fusion Positive Lung Adenocarcinoma.10
395550992024Case report: Treatment with ensartinib shows good response to SQSTM1-ALK fusion in lung adenocarcinoma.7
382669182024Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.0
307901502019Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report.0
293277182018Epithelioid fibrous histiocytoma: molecular characterization of ALK fusion partners in 23 cases.0
235883722013STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target.0
254135952015Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions.0
293291312018ALK Gene Fusions in Epithelioid Fibrous Histiocytoma: A Study of 14 Cases, With New Histopathological Findings.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
254135952015Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions.Jedrych J et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;5)(p23;q35) SQSTM1/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105459/t(2;5)(p23;q35)-sqstm1-alk