t(2;5)(p23;q35) SQSTM1/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

5q35.3

Gene name

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
211349802011Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma.27
293277182018Epithelioid fibrous histiocytoma: molecular characterization of ALK fusion partners in 23 cases.13
235883722013STAT3 pathway is activated in ALK-positive large B-cell lymphoma carrying SQSTM1-ALK rearrangement and provides a possible therapeutic target.10
307901502019Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report.4
254135952015Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions.4
293291312018ALK Gene Fusions in Epithelioid Fibrous Histiocytoma: A Study of 14 Cases, With New Histopathological Findings.3
297476762018Epithelioid cell histiocytoma with SQSTM1-ALK fusion: a case report.1

Article Bibliography

Pubmed IDLast YearTitleAuthors
254135952015Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL-ALK and SQSTM1-ALK gene fusions.Jedrych J et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;5)(p23;q35) SQSTM1/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105459/t(2;5)(p23;q35)-sqstm1-alk