t(2;7)(p23;q11) HIP1/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

HIP1

Location

7q11.23

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
362908952022Therapeutic Advances of Rare ALK Fusions in Non-Small Cell Lung Cancer.114
382052102023An advanced NSCLC patient with ALK-RNF144A and HIP1-ALK fusions treated with ALK-TKI combination therapy: a case report.46
273434442016Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma.36
255679082015Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches.36
352426312022High efficacy of alectinib in a patient with advanced lung adenocarcinoma with 2 rare ALK fusion sites: a case report.34
393181782024Successful treatment of a non-small-cell lung cancer patient harboring HIP1-ALK (H28:A20) and CTNNB1 p.S45del with alectinib.23
349410392021Identification of triple gene fusion ALK-LRRN2, LTBP1-ALK, and HIP1-ALK in advanced lung adenocarcinoma and response to alectinib: A case report.21
382297672024HIP1-ALK-Rearranged Lung Cancer in a Young Adult With BRAF V600E Mutation Detected After ALK Tyrosine Kinase Inhibitor Therapy: A Case Report.6
244960032014HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.0
346874882022Clinicopathological features and resistance mechanisms in HIP1-ALK-rearranged lung cancer: A multicenter study.0
332809262021A novel HIP1-ALK fusion variant in lung adenocarcinoma showing resistance to Crizotinib.0
245180942014HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.0
393035272024Targeted inhibition of NRF2 reduces the invasive and metastatic ability of HIP1 depleted lung cancer cells.0
253937962014Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib.0
318943862020Unique molecular features and clinical outcomes in young patients with non-small cell lung cancer harboring ALK fusion genes.0
315940412019[The characteristics of lung adenocarcinoma driver gene variants detected by high-throughput sequencing and quantitative fluorescence PCR].0

Article Bibliography

Pubmed IDLast YearTitleAuthors
244960032014HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.Fang DD et al
245180942014HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.Hong M et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;7)(p23;q11) HIP1/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105499/t(2;7)(p23;q11)-hip1-alk