t(7;7)(p11;p13) EGFR/PURB

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

EGFR

Location

7p11.2

Gene name

PURB

Location

7p13

Highly cited references

Pubmed IDYearTitleCitations
274137142016Kinase inhibitor-responsive genotypes in EGFR mutated lung adenocarcinomas: moving past common point mutations or indels into uncommon kinase domain duplications and rearrangements.22
292902552018EGFR-RAD51 fusion variant in lung adenocarcinoma and response to erlotinib: A case report.10
343420912021Gefitinib Combined with Cetuximab for the Treatment of Lung Adenocarcinoma Harboring the EGFR-Intergenic Region (SEC61G) Fusion and EGFR Amplification.2

Bibliography

Pubmed IDLast YearTitleAuthors
271020762016EGFR Fusions as Novel Therapeutic Targets in Lung Cancer.Konduri K et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(7;7)(p11;p13) EGFR/PURB

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/107528/t(7;7)(p11;p13)-egfr-purb