Metanephric tumors

2021-07-27   Paola Dal Cin 

1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)



Metanephric neoplasms comprise a spectrum of kidney tumors containing renal epithelial or stromal cells or both.


Metanephric tumorsGenetic event(s)
Metanephric adenoma BRAF V6000E mutation in 80% of the cases 1. Variant BRAF mutations were also reported 2. Genetic evidence for potential malignant evolution by acquiring pathogenic alterations in addition to BRAF, TERT promotor mutation, CDNK2A loss, MYC amp 3.
t(9;15)(p24;q24)/KANK1::NTRK3, lacking BRAF mutation mainly in young patients 4,5,6. Recurrent gain of chromosome 19 by array CGH 7.
Metanephric adenofibroma BRAF V6000E mutation in isolated cases 8.
Metanephric stromal tumor Predominantly affecting children, BRAF V600E mutations in most of the cases 8


Reference NumberPubmed IDLast YearTitleAuthors
1227279962012BRAF mutations in metanephric adenoma of the kidney.Choueiri TK et al
2301113512018Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases.Ding Y et al
3320646772020Molecular characterisation of metanephric adenomas beyond BRAF: genetic evidence for potential malignant evolution.Chan E et al
4157471022005Renal metanephric adenoma with previously unreported cytogenetic abnormalities: case report and review of the literature.Rakheja D et al
5285957332017A novel cytogenetic and molecular characterization of renal metanephric adenoma: Identification of partner genes involved in translocation t(9;15)(p24;q24).Catic A et al
6330460212020KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.Catic A et al
7208024692010Detection of chromosome copy number alterations in metanephric adenomas by array comparative genomic hybridization.Pan CC et al
8277698702017BRAF exon 15 mutations in pediatric renal stromal tumors: prevalence in metanephric stromal tumors.Marsden L et al


Paola Dal Cin

Metanephric tumors

Atlas Genet Cytogenet Oncol Haematol. 2021-07-27

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