Collecting duct carcinoma

2021-10-29   Paola Dal Cin , Michelle S. Hirsch 

1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
2.Department of Pathology, Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)

Classification

Definition

Collecting duct carcinoma (CDC) is a rare and aggressive renal epithelial neoplasm arising from the distal part of the collecting ducts (of Bellini) in the renal medulla.   Even nowadays, the diagnosis of CDC remains a diagnosis of exclusion.

Clinics and Pathology

Epidemiology

More likely to occur in middle to old age population, more common in males and in black than in white patients, both with a 2:1 ratio.

Clinical features

Patient may present with abdominal pain, gross hematuria, weight loss and a flank mass.

Macroscopic apperances

Well-defined or ill-defined mass in the renal medulla involving renal sinus, with frequent extension into the renal pelvis.

Histopathology

Prominent interstitial growth pattern with preserved glomeruli and renal tubules with several solid sheets/cords/nests, tubulopapillary and infiltrating glandular pattern with small-sized or medium-sized elongated tubules infiltrating in a desmoplastic stroma 1

Immunohistochemistry

SMARCB1(INI1) expression is retained; FH expression is retained, and OCT3/4 expression is completely negative.

Genetics

Cytogenetics

Various chromosomal and genomic alterations have been reported with inconsistent results. DNA losses are frequent, e.g., 1q, 6p, 8p, 9p and 21q as well as loss of Y 2,3.

Mutations

Several genomic alterations were detected, being NF2 (29%), SETD2 (24%), SMARCB1 (18%), and CDKN2A (12%) the most common, suggesting a potential role for mTOR inhibitors in patients with NF2 alterations 3.

Note

So far, there is no characteristic molecular genetic feature, or combination of features, useful for a definitive diagnosis. Molecular genetic testings should be considered after excluding other entities in the differential diagnosis (i.e., FH-deficient RCC, renal medullary carcinoma, papillary RCC) 4,5,6.

Cytogenetics

Prognosis and treatment

Of all renal cancers, CDC has the worst prognosis. Response to chemotherapy in CDC patients is modest to poor and overall survival is often less than 1 year.

Highly cited references

Pubmed IDYearTitleCitations
356875282022Assessing the QTcF prolongation of bedaquiline and delamanid coadministration to predict the cardiac safety of simplified dosing regimens.0
356683462022Population Pharmacokinetics of Delamanid and its Main Metabolite DM-6705 in Drug-Resistant Tuberculosis Patients Receiving Delamanid Alone or Coadministered with Bedaquiline.0
355862562022Thirty-two new and noteworthy floristic records from north-eastern Greece.0
354161422022Can food parenting practices explain the association between socioeconomic status and children's food intake? The Feel4Diabetes-study.0
351469482022Causes of mortality in elderly UICC stage III colon cancer (CC) patients--Tumor-related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry.1
346874172022Investigating the environmental Kuznets curve between economic growth and chemical fertilizer surpluses in China: a provincial panel cointegration approach.0
348433882022Population Pharmacokinetic and Concentration-QTc Analysis of Delamanid in Pediatric Participants with Multidrug-Resistant Tuberculosis.0
351407422021Expression Profile Analysis to Identify Circular RNA Expression Signatures in the Prolificacy Trait of Yunshang Black Goat Pituitary in the Estrus Cycle.0
347171162022Carbohydrate degradation contributes to the main bioheat generation during kitchen waste biodrying process: A pilot study.0
339932172021Racial Disparities in Invasive Haemophilus influenzae Disease-United States, 2008-2017.0
345294252021Synthesis and Characterizations of Two Tellurides β-BaGa2Te4 and Ba5Ga2Ge3Te12 with Flexible Chain Structure.0
344065862021Maternal Outcomes and Pregnancy-Related Complications Among Hospitalized Women with Inflammatory Bowel Disease: Report from the National Inpatient Sample.0
342222802021Epidemiology Profile of Viral Meningitis Infections Among Patients in Qatar (2015-2018).1
337139542021Development and validation of a liquid chromatography-tandem mass spectrometry method for quantifying delamanid and its metabolite in small hair samples.1
326205062021Lipoprotein (a) and risk for calcification of the coronary arteries, mitral valve, and thoracic aorta: The Multi-Ethnic Study of Atherosclerosis.2
331642202021Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate-Deficient Transferrin as Biomarkers of Alcohol Consumption.1
331771422020Development of a risk prediction model of potentially avoidable readmission for patients hospitalised with community-acquired pneumonia: study protocol and population.2
331581552020Mental Healthcare Utilization among Homeless People in the Greater Paris Area.0
331325632020Incidence of Medication Error in Critical Care Unit of a Tertiary Care Hospital: Where Do We Stand?1
327252442020Cost-effectiveness of a Stepwise Approach vs Standard Care for Diabetes Prevention in India.1
314745992020Comparative Persistence of Methotrexate and Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis.2
321624072020Dual renin-angiotensin-aldosterone blockade: Implementation of published research and Dear Doctor letters in ambulatory care: A retrospective observational study using prescription data.0
321658212020Giant Pituitary Adenoma Presenting with Foster-Kennedy Syndrome in a 21-Year Old Ethiopian Patient: A Rarely Reported Phenomenon: A Case Report.0
320191732020Associations of Dietary Sodium, Potassium, and Sodium to Potassium Ratio with Blood Pressure- Regional Disparities in China.3
317603092020Oral contraceptive and intrauterine device use and the risk of cervical intraepithelial neoplasia grade III or worse: a population-based study.4
315873762020Discovery of a role of the novel hepatokine, hepassocin, in obesity.4
318484392019A comparison between observed and DFT calculations on structure of 5-(4-chlorophenyl)-2-amino-1,3,4-thiadiazole.7
303384782019Comprehensive Word-Level Classification of Screening Mammography Reports Using a Neural Network Sequence Labeling Approach.2
311603482019Association between Liver Fibrosis and Serum PSA among U.S. Men: National Health and Nutrition Examination Survey (NHANES), 2001-2010.3
311716152019Complete Genome Sequence of Halomonas sulfidaeris Strain Esulfide1 Isolated from a Metal Sulfide Rock at a Depth of 2,200 Meters, Obtained Using Nanopore Sequencing.0
297976532018Late mortality and morbidity among long-term leukemia survivors with Down syndrome: A nationwide population-based cohort study.2
297313102018Trends in Dietary Sodium from Food Sources in Australian Children and Adolescents from 2007 to 2011/12.2
296540332018A UK clinical audit addressing the quality of prescribing of sodium valproate for bipolar disorder in women of childbearing age.3
292206432018Polygenic risk for alcohol consumption and its association with alcohol-related phenotypes: Do stress and life satisfaction moderate these relationships?9
297011542018Technological Solutions for Older People with Alzheimer's Disease: Review.9
306030302018Uric acid and contrast-induced nephropathy: an updated review and meta-regression analysis.1
290796032017Combination of obstructive sleep apnoea and insomnia treated by continuous positive airway pressure with the SensAwake pressure relief technology to assist sleep: a randomised cross-over trial protocol.1
282228242017Curiosity killed the cat: no evidence of an association between cat ownership and psychotic symptoms at ages 13 and 18 years in a UK general population cohort.5
292045822017Publication trends in obstructive sleep apnea: Evidence of need for more evidence.2
282541262017Economic Value and Cost-Effectiveness of Cardiac Resynchronization Therapy Among Patients With Mild Heart Failure: Projections From the REVERSE Long-Term Follow-Up.9
280750422017Protein induced by vitamin K absence or antagonist II (PIVKA-II) producing large cell neuroendocrine carcinoma (LCNEC) of lung with multiple liver metastases: A case report.1
279399202017Gamma-glutamyl transferase and atrial fibrillation in patients with coronary artery disease.2
278768202017A method to customize population-specific arrays for genome-wide association testing.7
276516152016Field Testing of Second Generation of Colour-Coded Rings for Detecting Slow Progress of Labour at Rural Health Centres.0
275115322016Flexible Batteries: Hierarchical Assemblies of Carbon Nanotubes for Ultraflexible Li-Ion Batteries (Adv. Mater. 31/2016).0
268877602016Field Testing of Appropriate Technological Tool of Individualised Color Coded Any Day Neonatal Growth Monitoring Charts for Neonatal Care at Primary Health Care Level.0
278376212016E-cadherin-160 C/A genotypes and cervical intraepithelial neoplasia.1
265972942015Candida concentrations determined following concentrated oral rinse culture reflect clinical oral signs.10
263881192015Impact of tornadoes on hospital admissions for acute cardiovascular events.1
263193002015Simultaneous quantitation of delamanid (OPC-67683) and its eight metabolites in human plasma using UHPLC-MS/MS.5
254801452015Clinical features and in-hospital mortality associated with different types of atrial fibrillation in patients with acute coronary syndrome with and without ST elevation.13
259591702015Complete genome sequence of Paenibacillus riograndensis SBR5(T), a Gram-positive diazotrophic rhizobacterium.4
260312112015Antenatal dietary education and supplementation to increase energy and protein intake.73
259424242015Decline in Coronary Mortality in Sweden between 1986 and 2002: Comparing Contributions from Primary and Secondary Prevention.6
266879572015Risk of bleeding and arterial thromboembolism in patients with non-valvular atrial fibrillation either maintained on a vitamin K antagonist or switched to a non-vitamin K-antagonist oral anticoagulant: a retrospective, matched-cohort study.33
248945162014Global protein-protein interaction network of rice sheath blight pathogen.5
247874712014Extravirgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención con Dieta Mediterránea) trial.57
248929642014Herpes zoster-attributable resource utilization and cost burden in patients with solid organ transplant.4
248848212014Sweetened beverage consumption and the risk of hyperuricemia in Mexican adults: a cross-sectional study.12
245236672014Patterns of obesity development before the diagnosis of type 2 diabetes: the Whitehall II cohort study.34
247998612014Prevalence and risk factors associated with preterm birth in Ardabil, Iran.22
243415682013Group involvement and self-rated health among the Japanese elderly: an examination of bonding and bridging social capital.15
234542582013Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest.43
233380492013Metabolic/bariatric surgery worldwide 2011.241
232576912013Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis.7
243267912013Watering cattle (young bulls) with brackish water--a hazard due to its salt content?0
224110702012Cancer incidence in Czech black coal miners in association with coalworkers' pneumoconiosis.7
222614302012A retrospective service audit of a mobile physiotherapy unit on the PGA European Golf Tour.3
219530662012Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents.35
221944822012Is there a role for FDG PET in the management of lung cancer manifesting predominantly as ground-glass opacity?21
2219982320112,3-Diamino-pyridinium 6-carb-oxy-pyridine-2-carboxyl-ate.1
218682112011The role of intergenerational influence in waste education programmes: the THAW project.2
223362732011[Analysis of inpatient cost of AIDS related opportunistic infection in a high HIV epidemic area].0
214848372011Alkali metal atom-aromatic ring: a novel interaction mode realizes large first hyperpolarizabilities of M@AR (M=Li, Na, and K, AR=pyrrole, indole, thiophene, and benzene).0
214606752011Three-dimensional white light camera to aid lipoabdominoplasty: a pilot project.0
222202792011Peripheral arterial disease in patients presenting with acute coronary syndrome in six middle eastern countries.10
198985102010Pharmacokinetics of CsA during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation.4
203977902010Anticholinesterase duration in the Australian veteran population.4
197620242010The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome.34
2157781620091,1'-Dimethyl-4,4'-[(2,4-diphenyl-cyclo-butane-1,3-di-yl)dipyridinium-(E)-1-methyl-4-styrylpyridinium-benzene-sulfonate (0.15/1.70/2).2
194339872009Crying and feeding problems in infancy and cognitive outcome in preschool children born at risk: a prospective population study.16
188346682008Taenia solium porcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole.29
186081162008Coronary angioplasty in drug eluting stent era for the treatment of unprotected left main stenosis compared to coronary artery bypass grafting.8
182102862008Correlations between body measurements and tissue composition of oat-fattened White Kołuda geese at 17 weeks of age.2
174679142007A comparison study between early enteral nutrition and parenteral nutrition in severe burn patients.12
176367342007Antibiotic prophylaxis for hernia repair.8
166217002006Non-fatal sports and recreational violent injuries among children and teenagers, United States, 2001-2003.6
161896132005Surface tension of a Lennard-Jones liquid under supersaturation.2
157892682005Genome segment RNA-1 of a flat apple isolate of Cherry rasp leaf virus: nucleotide sequence analysis and RT-PCR detection.1
159116462005Social dynamics of health inequalities: a growth curve analysis of aging and self assessed health in the British household panel survey 1991-2001.18
153541122004Primary closure for postoperative mediastinitis in children.6
152239872004Indicators of abdominal adiposity in middle-aged participants of the SU.VI.MAX study: relationships with educational level, smoking status and physical inactivity.9
145853192003Annual screening for oral cancer detection.7
109358212000Energy deficits associated with nasogastric feeding in patients with burns.0
105624191999Investigating site-specific effects of the -X glutamate in a parvalbumin CD site model peptide.2
101963231999Genetic and phenotypic changes accompanying the emergence of epizootic subtype IC Venezuelan equine encephalitis viruses from an enzootic subtype ID progenitor.27
97139121998Failure to learn human immunodeficiency virus test results in Los Angeles public sexually transmitted disease clinics.8
96107831998Risk factors for breast cancer in women with a breast cancer family history.12
95010971998A common role of CRP in transcription activation: CRP acts transiently to stimulate events leading to open complex formation at a diverse set of promoters.15
75673381995Hospital readmission due to neonatal hyperbilirubinemia.14

Bibliography

Reference NumberPubmed IDLast YearTitleAuthors
1293093002018Reappraisal of Morphologic Differences Between Renal Medullary Carcinoma, Collecting Duct Carcinoma, and Fumarate Hydratase-deficient Renal Cell Carcinoma.Ohe C et al
2241676002013Collecting duct carcinomas represent a unique tumor entity based on genetic alterations.Becker F et al
3261496682016Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling.Pal SK et al
4281819502017Clinicopathologic and Molecular Pathology of Collecting Duct Carcinoma and Related Renal Cell Carcinomas.Seo AN et al
5319058212019Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach.Alaghehbandan R et al
6322510072020Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: III: Molecular Pathology of Kidney Cancer.Williamson SR et al

External Links

Citation

Paola Dal Cin ; Michelle S. Hirsch

Collecting duct carcinoma

Atlas Genet Cytogenet Oncol Haematol. 2021-10-29

Online version: http://atlasgeneticsoncology.org/solid-tumor/208921/collecting-duct-carcinoma