Chondro-osseous tumors
2021-10-04 Paola Dal Cin, PhD Affiliation1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)
Classification
Definition
Chondro-osseous tumors comprise various types of soft tissue lesions and may contain bone or cartilage matrix. The evidence of bona fide osteo-cartilaginous matrix is the prerequisite. Most of these matrices are considered to be formed through metaplastic or heterologous differentiation in areas of the tumors.
| Chondro-osseous tumors | Genetic event(s) | ||
|---|---|---|---|
| Soft tissue chondroma | Cytogenetically detectable 12q13-15 rearrangements, but HMGA2 transcripts also detected in cases without microscopically 12q involvement 1 | ||
| FN1 rearrangements with either FGFR1 or FGFR2 2 | |||
| Extraskeletal osteosarcoma | Genomic signature overlaps with conventional skeletal osteosarcoma Highly complex karyotypes with losses / gains/amplification. Recurrent mutational events in genes affecting mainly numerous cancer related- pathways: tumour suppressor genes including cell cycle checkpoint genes, chromatin remodeling genes, histone methylation and demethylation genes and WNT and Sonic Hedghog pathways genes 3 |
Article Bibliography
| Reference Number | Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|---|
| 1 | 14614053 | 2003 | Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. | Dahlén A et al |
| 2 | 31273315 | 2019 | Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement. | Amary F et al |
| 3 | 27499911 | 2016 | The molecular landscape of extraskeletal osteosarcoma: A clinicopathological and molecular biomarker study. | Jour G et al |
Citation
Paola Dal Cin, PhD
Chondro-osseous tumors
Atlas Genet Cytogenet Oncol Haematol. 2021-10-04
Online version: http://atlasgeneticsoncology.org/solid-tumor/208937/chondro-osseous-tumors
