Chondro-osseous tumors

2021-10-04   Paola Dal Cin 

1.Brigham and Women's Hospital , Harvard Medical School, Boston , MA (USA)



Chondro-osseous tumors comprise various types of soft tissue lesions and may contain bone or cartilage matrix. The evidence of bona fide osteo-cartilaginous matrix is the prerequisite. Most of these matrices are considered to be formed through metaplastic or heterologous differentiation in areas of the tumors.

Chondro-osseous tumorsGenetic event(s)
Soft tissue chondromaCytogenetically detectable 12q13-15 rearrangements, but HMGA2 transcripts also detected in cases without microscopically 12q involvement 1
FN1 rearrangements with either FGFR1 or FGFR2 2
Extraskeletal osteosarcoma Genomic signature overlaps with conventional skeletal osteosarcoma Highly complex karyotypes with losses / gains/amplification. Recurrent mutational events in genes affecting mainly numerous cancer related- pathways: tumour suppressor genes including cell cycle checkpoint genes, chromatin remodeling genes, histone methylation and demethylation genes and WNT and Sonic Hedghog pathways genes 3


Reference NumberPubmed IDLast YearTitleAuthors
1146140532003Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas.Dahlén A et al
2312733152019Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement.Amary F et al
3274999112016The molecular landscape of extraskeletal osteosarcoma: A clinicopathological and molecular biomarker study.Jour G et al

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Paola Dal Cin

Chondro-osseous tumors

Atlas Genet Cytogenet Oncol Haematol. 2021-10-04

Online version: