Kidney: Renal Oncocytoma

2008-04-01   Hyun-Jung Kim , Federico A Monzon 

1.Inje University, Sanggye Paik Hospital, Seoul, Korea (HJK); The Methodist Hospital, The Methodist Hospital Research Institute, Houston, TX, USA (FAM)
2.Department of Pathology, Brigham and Womens Hospital, 75 Francis Street, Boston, MA 02115, USA



Renal Oncocytoma is a benign renal epithelial neoplasm that comprises approximately 5-9% of renal tubular epithelial tumors.

Clinics and Pathology

Embryonic origin

Many investigators have suggested that these tumors originate from intercalated cells of the collecting system.


Renal oncocytomas can present in familial or sporadic forms. Oncocytomas may be seen in patients with Birt-Hogg-Dube syndrome (BHD, who carry germline mutations in the folliculin gene (FLCN). However, sporadic cases are much more common and have an unknown etiology.


Renal oncocytomas account for about 5-9% of all renal tumors and occur across a broad age range, peaking in the seventh decade. There is a male predominance (2:1) and tumors are frequently small and found incidentally. A rare association between oncocytoma and angiomyolipoma or tuberous sclerosis has been reported..


Macroscopically, renal oncocytomas are well-circumscribed, slightly lobulated solid tumors with generally mahogany brown or dark red cut surface. The tumors are typically solitary, but can be multifocal or bilateral. A central scar is frequently observed. Some cases show involvement of the perinephric fat or rarely the renal vein with no change in prognosis. Microscopically, the tumor is composed of nests and tubular structures made up from oncocytic cells, and is frequently associated with fibrous or edematous stroma. The tumor cells are large round eosinophilic cells with granular cytoplasm that is packed with mitochondria. Nuclei are round and monomorphic and contain small nucleoli. Tumor cells around the central scar are small with scant cytoplasm. Bizarre cells with pleomorphic nuclei may be present in some tumors and have no affect on outcome. Mitoses and necrosis are not seen. Tumor cells are typically immunoreactive for KIT, S100A (multifocal), and HNF1beta, and are negative for CD10, AMACR and vimentin. CK7 is usually negative or patchy positive with immunoreactivityini single scattered cells; this is in contrast to chromophobe renal cell carcinoma which shows diffuse membranous positivity.
Rare cases that show multiple oncocytic tumors can be referred to as oncocytosis. Oncocytosis, as well as hybrid oncocytic tumors may occur sporadically or in association with Birt-Hogg-Dubé syndrome. .
Atlas Image
Figure 1A: Oncocytoma is a benign renal epithelial neoplasm. Oncocytomas contain small oncocytic cells with round, regular nuclei that sometimes contain a small nucleolus. Architecturally the tumors are solid, nested or tubular, and are frequently associated with edematous stroma.
Atlas Image
Figure 1B: Occasionally oncocytomas extend into perinephric adipose tissue; this findings has no affect on clinical outcome (i.e., the tumor is still benign).
Atlas Image
Figure 1C: A small subset of oncocytomas demonstrate nuclear atypia and/or multinucleation. Some think this is due to degenerative change. Regardless, these nuclear features do not affect clinical outcome (i.e., the tumor is still benign).


Most patients with RO are treated with nephrectomy. Nephrectomy (radical or partial). Enucleation, wedge resection or ablation may also be considered for treatment options but are less common.


Oncocytomas behave in a benign fashion. Atypical pathologic features, such as nuclear pleomorphism, perinephric fat involvement and extension into renal vein branches do not influence prognosis.



Oncocytomas frequently exhibit losses of chromosome 1/1p-, chromosome 14 and/or a sex chromosome. Structural rearrangements of 11q13 have been reported, with t(5;11) and t(9;11) representing the most common translocations. A t(6;9)(p21;p23) has been reported in three cases of oncocytoma (Balzarini et al., 1999; Hudacko et al., 2011). A subset of oncocytomas exhibit non-recurrent numerical or structural abnormalities A normal karyotype is also frequently observed.
One of the diagnostic pitfalls in renal epithelial tumors is distinguishing between benign RO from the eosinophillic variant of chromophobe carcinoma. Many studies have reported that chromophobe RCC shows complex simultaneous losses of chromosomes 1, 2, 6, 10, 13, 17, and 21. Although occasional losses of all these chromosomes have been reported in RO, the simultaneous loss of all these chromosomes has not been seen in oncocytomas.

Genes Involved and Proteins

Gene name

FLCN (folliculin gene)




Germline mutations in FLCN cause Birt-Hogg-Dubé syndrome, an inherited disorder characterized by follicular hamartomas, renal tumors, pulmonary cysts, and spontaneous pneumothorax. Hybrid oncocytic/chromophobe tumors and chromophobe renal cell carcinomas are the most common renal tumors in Birt-Hogg-Dubé syndrome, but oncocytomas may be seen in a subset of cases. The renal tumors are typically bilateral and multifocal.

Protein description

Folliculin is a putative tumor suppressor that plays a role in the regulation of energy homeostasis and AMPK and CC: TXT: mTOR ID: 40639> signaling.

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Pubmed IDLast YearTitleAuthors
159932672005Losses of 1p and chromosome 14 in renal oncocytomas.Füzesi L et al
181561592008Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.Gasparre G et al
180665902008Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features.Hes O et al
116848512001Familial and sporadic renal oncocytomas--a comparative molecular-genetic analysis.Junker K et al
264283182015Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dubé tumors.Lang M et al
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184138152008Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.Mayr JA et al
182460492008Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors.Monzon FA et al
151862682004Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changes.Nagy A et al
172271272007High incidence of chromosome 1 abnormalities in a series of 27 renal oncocytomas: cytogenetic and fluorescence in situ hybridization studies.Paner GP et al
182852592008Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization.Picken MM et al
166978632006Classification of renal neoplasms based on molecular signatures.Yang XJ et al

External Links


Hyun-Jung Kim ; Federico A Monzon

Kidney: Renal Oncocytoma

Atlas Genet Cytogenet Oncol Haematol. 2008-04-01

Online version:

Historical Card

0000-00-00 Kidney: Renal Oncocytoma by  Kelsey McIntyre,Michelle S. Hirsch 

Department of Pathology, Brigham and Womens Hospital, 75 Francis Street, Boston, MA 02115, USA