Liver tumors: an overview

2008-05-01   Munechika Enjoji  

1.Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan

Classification

Classification

WHO histological classification of the liver and intrahepatic bile ducts.
  • Epithelial tumors
    • Benign:
    • Malignant:
      • Hepatocellular carcinoma
      • Intrahepatic cholangiocarcinoma
      • Bile duct cystadenocarcinoma
      • Combined hepatocellular and cholangiocarcinoma
      • Hepatoblastoma
      • Undifferentiated carcinoma
  • Non-epithelial tumors
  • Miscellaneous tumors
      • Solitary fibrous tumor
      • Teratoma
      • York sac tumor
      • Carcinosarcoma
      • Rhabdoid tumor
      • Others
  • Hematopoietic and lymphoid tumors
  • Secondary tumors
  • Epithelial abnormalities
      • Liver cell dysplasia
      • Dysplastic nodules
      • Bile duct abnormalities
  • Miscellaneous lesions
      • Mesenchymal hamartoma
      • Nodular transformation
      • Inflammatory pseudotumor

    • Article Bibliography

    Pubmed IDLast YearTitleAuthors
    166133232006Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocellular and cholangiocarcinoma.Aishima S et al
    128464052003Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours.Altimari A et al
    176517852007Inverse expression of Jun activation domain binding protein 1 and cell cycle inhibitor p27Kip1: influence on proliferation in hepatocellular carcinoma.Berg JP et al
    152884792004Clinical and molecular analysis of combined hepatocellular-cholangiocarcinomas.Cazals-Hatem D et al
    81290311994Immunohistochemical detection of bcl-2 protein in normal and pathological human liver.Charlotte F et al
    122978402002P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia.Chen YW et al
    112608642001Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study.Cong WM et al
    179628102008Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.Curia MC et al
    110145642000Genetic classification of combined hepatocellular-cholangiocarcinoma.Fujii H et al
    155665042004Alterations of p53, Bcl-2, and hMSH2 protein expression in the cirrhotic, macroregenerative, dysplastic nodules and hepatocellular carcinomas in Upper Egypt.Hussein MR et al
    89570641996Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.Imai Y et al
    102120001999Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.Kang YK et al
    119146282002Expression of KIT (CD117) in angiomyolipoma.Makhlouf HR et al
    155888502005Cytogenetic abnormalities in hepatoblastoma: report of two new cases and review of the literature suggesting imbalance of chromosomal regions on chromosomes 1, 4, and 12.Nagata T et al
    163976102006Cholangiocarcinoma.Patel T et al
    83812451993Immunolocalization of ras oncogene p21 in human liver diseases.Radosevich JA et al
    150309832004Multiple chromosomal abnormalities in human liver (pre)neoplasia.Raidl M et al
    103899811999Different gene expression of MDM2, GAGE-1, -2 and FHIT in hepatocellular carcinoma and focal nodular hyperplasia.Schlott T et al
    129105092003Where do we stand with hepatoblastoma? A review.Schnater JM et al
    98649691998Prognostic significance of Ki-67 and p53 antigen expression in carcinomas of bile duct and gallbladder.Shrestha ML et al
    110345922000Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.Tannapfel A et al
    98229211998c-erbB-2 protein is expressed in hepatolithiasis and cholangiocarcinoma.Terada T et al
    127688752003Cytogenetic alterations in liver cell tumors as detected by comparative genomic hybridization.Terracciano L et al
    168585372006Role of epigenetic alterations in cholangiocarcinoma.Tischoff I et al
    119043352002Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway.Torbenson M et al
    79264621994Point mutation of K-ras gene codon 12 in biliary tract tumors.Watanabe M et al
    91103011997Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma: analysis of estrogen receptors/progesterone receptors and expression of tumor-associated antigens.Weihing RR et al
    93651691997Overexpression of hepatic prothymosin alpha, a novel marker for human hepatocellular carcinoma.Wu CG et al
    77964001995Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.Yoshida S et al

    Citation

    Munechika Enjoji

    Liver tumors: an overview

    Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

    Online version: http://atlasgeneticsoncology.org/solid-tumor/5273/liveroverviewid5273