| Written | 2005-05 | Antonio Cuneo, Gianluigi Castoldi |
| Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9702/3 Peripheral T-cell lymphoma, NOS; Anaplastic large cell lymphoma, ALK negative |
| Atlas_Id | 2035 |
| Clinics and Pathology |
| Phenotype / cell stem origin | These are peripheral T-cell tumours, usually expressing CD4 along with other T-cell markers. The CD30 molecule is expressed in a histologically distinct subset (vide infra). Classification: The WHO identifies some well-defined clinicopathological entities with distinct clinical behaviour. Indolent forms include mycosis fungoides, primary cutaneous CD30 (Ki1) positive anaplastic large cell lymphomas and its benign variant lymphomatous papulosis; aggressive forms include Sezary's syndrome and peripheral CD30-negative T-cell lymphoma. |
| Epidemiology | Primary cutaneous non Hodgkin's lymphomas (NHL) has an approximate 0,4/100.000 incidence in the U.S. The majority of patients are between 40 and 60 years old. |
| Clinics | Details on clinics, pathology, cytogenetics and molecular cytogenetics can be found in disease-specific cards (i.e. mycosis fungoides / Sezary's syndrome, primary cutaneous CD30 positive anaplastic large cell lymphoma). |
| Bibliography |
| Lymphoma of the skin. |
| Connors JM, His E, Foss F |
| ASH educational book, pp. 1926. |
| Cutaneous T cell lymphomas. |
| Wilson LD, Jones G, Kacinski B, Edelson R, Heald P |
| In.. |
| Citation |
| This paper should be referenced as such : |
| Cuneo, A ; Castoldi, GL |
| Cutaneous T-cell lymphomas |
| Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):241-241. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/CutanTcellID2035.html |
| Other genes implicated (Data extracted from papers in the Atlas) [ 14 ] |
| Genes | BMI1 | CXCL10 | DIABLO | DPP4 | EEF1A1 | FAS | IL7R | MIR122 | MYBL2 | NFKB2 |
| PLCG1 | PTK6 | PTPN6 | PTPRG |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Jun 30 11:22:07 CEST 2017 |
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