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Cutaneous T-cell lymphomas

Written2005-05Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9702/3 Peripheral T-cell lymphoma, NOS; Anaplastic large cell lymphoma, ALK negative
Atlas_Id 2035

Clinics and Pathology

Phenotype / cell stem origin These are peripheral T-cell tumours, usually expressing CD4 along with other T-cell markers. The CD30 molecule is expressed in a histologically distinct subset (vide infra).
Classification: The WHO identifies some well-defined clinicopathological entities with distinct clinical behaviour. Indolent forms include mycosis fungoides, primary cutaneous CD30 (Ki1) positive anaplastic large cell lymphomas and its benign variant lymphomatous papulosis; aggressive forms include Sezary's syndrome and peripheral CD30-negative T-cell lymphoma.
Epidemiology Primary cutaneous non Hodgkin's lymphomas (NHL) has an approximate 0,4/100.000 incidence in the U.S. The majority of patients are between 40 and 60 years old.
Clinics Details on clinics, pathology, cytogenetics and molecular cytogenetics can be found in disease-specific cards (i.e. mycosis fungoides / Sezary's syndrome, primary cutaneous CD30 positive anaplastic large cell lymphoma).

Bibliography

Lymphoma of the skin.
Connors JM, His E, Foss F
ASH educational book, pp. 1926.
 
Cutaneous T cell lymphomas.
Wilson LD, Jones G, Kacinski B, Edelson R, Heald P
In..
 

Citation

This paper should be referenced as such :
Cuneo, A ; Castoldi, GL
Cutaneous T-cell lymphomas
Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):241-241.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/CutanTcellID2035.html

Other genes implicated (Data extracted from papers in the Atlas) [ 15 ]

Genes BMI1 CXCL10 DIABLO DPP4 EEF1A1 FAS IDH2 IL7R MIR122 MYBL2
NFKB2 PLCG1 PTK6 PTPN6 PTPRG

External links

COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMapTopo ( C42) Morph ( 9702/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaseCutaneous T-cell lymphomas
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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