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Infant leukaemias

Congenital leukaemias

Neonatal leukaemias

Written1999-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1084
Note
  • infant or congenital leukaemias are defined by a diagnosis within either the first month, the first year, or the first two years of life, according to different workers; recent data have shown that patients, diagnosed to have a leukaemia at age 5 mths and 2 yrs, already had a MLL-AF4 fusion gene in their neonatal blood spots/Guthrie cards
  • infant leukaemias have been suspected to have an environmental component:
    1- some of the leukaemias known to be often related to genotoxic exposure, such as the 11q23 leukaemias and the t(8;16) leukaemia, may also be found in infants;
    2- there has been a significant increase in infant acute leukaemias incidence of around 2.5% per year for 15 yrs, suggesting the presence of an environmental factor;
    3- infants with leukaemia (excluding Down syndrome cases) have more congenital anomalies (heart defects, digestive tract anomalies, mental delay)

  • they may be myelodysplasia or acute myeloid leukaemia (M4 or M5 mainly) in 1/2 to 2/3 of cases, or B-cell acute lymphocytic leukaemia (CD19+ or CD10+) in the remaining cases
  • sex ratio is balanced, both in AML and in ALL cases
  • frequent CNS involvement; WBC is often high, whatever the chromosome anomaly is; skin infiltrations (leukaemia cutis) may occur
  • 11q23 is found involved in 1/3 to 1/2 of cases (t(4;11), t(9;11), and t(11;19) representing nearly 1/10 of cases each)
    See also 11q23 rearrangements in childhood acute lymphoblastic leukemia: Clinical aspects
  • 4yr event free survival in infants ALL is 1/3 and median event free survival (EFS) is 1yr
  • in infants aged less than a month, 6 months survival is only 1/3, both in AML and in ALL
  • as the prognosis is most often very poor, bone marrow transplantation is indicated, apart in infant leukemia of the Down syndrome patient, were the prognosis is good
    		•

    Clinics and Pathology

    Disease Infant myelodysplasia
    Note they most often exhibit a normal karyotype or a monosomy 7
    Etiology exhibit a genetic background or is considered as idiopathic
    Epidemiology annual incidence : about 1 case per 106
    Prognosis has herein been calculated from 3 large studies (n= 47) : median survival was 31 mths; 6 yr survival was 43%

    Disease Down syndrome with M7
    Note Down syndrome patients have been known for long to be at increased risk (10 to 30 fold) of both ALL and AML; ALL is similar in Down syndrome (DS) and in the general population, whereas AML in DS is most often a specific entity of acute megakaryoblastic leukaemia (M7-AML); at least 20% of leukaemias in DS are M7, and other cases of M7-AML may also be misclassified as undifferentiated leukaemias or as ALL; therefore, the risk of M7 may well be 500 to 1000 times greater when the child has a DS; in other words, it may be that half of infants with M7 are DS ... and also that the risk of ALL in DS may not be as increased as previously claimed
    Epidemiology M7 leukaemia in Down syndrome infants annual incidence : 0.2 case per 106; median age at diagnosis is 22-23 mths
    Clinics there is often a preceeding myelodysplasia, or history of transient leukemoid reaction (a disease of the megakaryocytic lineage)
    Prognosis M7-AML has proved to be of better prognosis when in DS, with a recent study on 65 DS patients with M7, showing a 4 yr event free survival of 73%

    Disease 11q23 abnormalities
    Phenotype / cell stem origin M4 or M5 acute myeloid leukaemia (AML) or CD19+ B-cell acute lymphocytic leukaemia (ALL);
    Epidemiology 25% of 11q23 rearrangements cases are infant (<1 yr) cases; as much as 2/3 of cases of infant ALL leukaemias have been found in some studies to carry a 11q23 rearrangement, especially in infants < 6 mths old; a third to a half of infant AML cases also have a 11q23 rearrangement; however, 11q23 leukaemias can also be seen in children and in adults
    Clinics organomegaly; frequent CNS involvement; high WBC
    Prognosis median survival of 1yr, and a 3yr event free survival of 13% in a study and a 4 yr event free survival of 15% in another

  • t(4;11)(q21;q23) : CD19+ B-ALL; unbalanced sex ratio < 4 yrs (1M/2F); infants (<1 yr) accounting for 1/3 of t(4;11) cases; annual incidence could be 0.3-0.5 case per 106; prognosis: med EFS 7 mths; med survival 29mths; 3yr survival 40%; 3yr EFS: 30%; the gene involved in 4q21 is AF4

  • t(9;11)(p23;q23) : found in M5a or M4 AML; the rare ALL cases of t(9;11) are most often found in infants; infants cases (<1 yr) account for 15% of all t(9;11) cases; med EFS: 1yr, 3yr EFS 20%; the gene involved in 9p22 is AF9

  • t(10;11)(p12;q23) : rare; M4 or M5 AML; ALL at times; infants represent 40% of cases; the gene involved in 10p12 is AF10

  • t(11;19)(q23;p13.3): ALL, biphenotypic AL and M4 or M5 AML; half cases of t(11;19)(q23;p13.3) are infant cases; a study on 40 cases showed that med survival was 5 mths, with a 2yr survival of 20% (unpublished observation); the gene involved in 19p13.3 is ENL

  • other 11q23 rearrangements are rarely found in infants leukaemias

  • in 11q23 sits MLL, which encodes a 431 kDa protein; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation; wide expression; homology with trithorax (drosophila); the fusion protein includes the N-term AT hook and DNA methyltransferase from MLL fused to (little or most of) the partner C-term part from the other chromosome

    • Disease t(1;22)(p13;q13)
    Phenotype / cell stem origin M7 AML
    Epidemiology 39 cases so far described; <0.1 case per 106 (perhaps much less); the only leukaemia (nearly) restricted to infant cases; median age is 4 mths
    Clinics organomegaly, bone marrow fibrosis; misdiagnosis of a solid tumour is frequent
    Prognosis remission is obtained in only half cases, median survival is 7 mths

    Disease 12p abnormalities
    Phenotype / cell stem origin B lineage ALL mainly (CD10+); M5 AML at times
    Epidemiology at least 9 cases
    Prognosis no sufficient data

    Disease inv(16)(p13q22)
    Phenotype / cell stem origin M4 AML
    Epidemiology at least 3 cases reported
    Clinics high WBC, CNS involvement
    Prognosis is very poor so far (remission duration : 0, 2, 6 mths), in contrast with the usual inv(16) prognosis

    Disease t(5;15)(p15;q11)
    Phenotype / cell stem origin B lineage ALL
    Epidemiology 5 known cases
    Prognosis unknown; CR in 5/5

    Disease t(8;16)(p11;p13)
    Phenotype / cell stem origin M5/M4 AML
    Epidemiology at least 3 cases
    Prognosis survival : 0.5 mth, 22 mths+, 24 mths+

    Disease +19 and/or +21
    Phenotype / cell stem origin AML and ALL
    Epidemiology at least 5 cases
    Prognosis no survival data available

    Disease other chromosome rearrangements : +8 (solely or not), found in a few cases, del(6q), , and non recurring anomalies, found in at least one case each; finally, the kayotype has been found to be normal in a percentage of cases

    Bibliography

    Forty-four cases of childhood myelodysplasia with cytogenetics, documented by the Groupe Français de Cytogéné Hématologique.
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1997 ; 11 (9) : 1478-1485.
    PMID 9305601
     
    Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group.
    Bernstein J, Dastugue N, Haas OA, Harbott J, Heerema NA, Huret JL, Landman-Parker J, LeBeau MM, Leonard C, Mann G, Pages MP, Perot C, Pirc-Danoewinata H, Roitzheim B, Rubin CM, Slociak M, Viguie F
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (1) : 216-218.
    PMID 10637500
     
    Myelodysplastic syndrome in children: differentiation from acute myeloid leukemia with a low blast count.
    Chan GC, Wang WC, Raimondi SC, Behm FG, Krance RA, Chen G, Freiberg A, Ingram L, Butler D, Head DR
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1997 ; 11 (2) : 206-211.
    PMID 9009082
     
    Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome.
    Chen CS, Sorensen PH, Domer PH, Reaman GH, Korsmeyer SJ, Heerema NA, Hammond GD, Kersey JH
    Blood. 1993 ; 81 (9) : 2386-2393.
    PMID 8481519
     
    [Acute myeloid leukemia in children with Down syndrome]
    Creutzig U, Ritter J, Ludwig WD, Niemeyer C, Reinisch I, Stollmann-Gibbels B, Zimmermann M, Harbott J
    Klinische Padiatrie. 1995 ; 207 (4) : 136-144.
    PMID 7564143
     
    Spontaneous remission of congenital leukemia.
    Dinulos JG, Hawkins DS, Clark BS, Francis JS
    The Journal of pediatrics. 1997 ; 131 (2) : 300-303.
    PMID 9290620
     
    Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots.
    Gale KB, Ford AM, Repp R, Borkhardt A, Keller C, Eden OB, Greaves MF
    Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (25) : 13950-13954.
    PMID 9391133
     
    Acute megakaryoblastic leukemia.
    Gassman W, Lö H
    Leukemia Lymphoma. 1995 ; 18 (numero Suppl 1) : 61-63.
     
    Infant leukaemia biology, aetiology and treatment.
    Greaves MF
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (2) : 372-377.
    PMID 8637251
     
    Pathogenesis, biology, and management of myelodysplastic syndromes in children.
    Haas OA, Gadner H
    Seminars in hematology. 1996 ; 33 (3) : 225-235.
    PMID 8819232
     
    Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group.
    Heerema NA, Arthur DC, Sather H, Albo V, Feusner J, Lange BJ, Steinherz PG, Zeltzer P, Hammond D, Reaman GH
    Blood. 1994 ; 83 (8) : 2274-2284.
    PMID 8161794
     
    Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytogenetic analyses of 48 patients--updated published cases and 16 new observations.
    Huret JL, Brizard A, Slater R, Charrin C, Bertheas MF, Guilhot F, Hählen K, Kroes W, van Leeuwen E, Schoot EV
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1993 ; 7 (2) : 152-160.
    PMID 8426468
     
    Hematologic malignancies with t(4;11)(q21;q23)--a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. European 11q23 Workshop participants.
    Johansson B, Moorman AV, Haas OA, Watmore AE, Cheung KL, Swanton S, Secker-Walker LM
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 779-787.
    PMID 9593281
     
    Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastic leukemia.
    Köller U, Haas OA, Ludwig WD, Bartram CR, Harbott J, Panzer-Grümayer R, Hansen-Hagge T, Ritter J, Creutzig U, Knapp W
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1989 ; 3 (10) : 708-714.
    PMID 2779287
     
    Clinical characteristics of infant acute leukemia with or without 11q23 translocations.
    Kaneko Y, Shikano T, Maseki N, Sakurai M, Sakurai M, Takeda T, Hiyoshi Y, Mimaya J, Fujimoto T
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1988 ; 2 (10) : 672-676.
    PMID 3172843
     
    Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891.
    Lange BJ, Kobrinsky N, Barnard DR, Arthur DC, Buckley JD, Howells WB, Gold S, Sanders J, Neudorf S, Smith FO, Woods WG
    Blood. 1998 ; 91 (2) : 608-615.
    PMID 9427716
     
    The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients. European 11q23 Workshop participants.
    Lillington DM, Young BD, Berger R, Martineau M, Moorman AV, Secker-Walker LM
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 801-804.
    PMID 9593284
     
    Review of the cytogenetic changes in acute megakaryoblastic leukemia: one disease or several?
    Lu G, Altman AJ, Benn PA
    Cancer genetics and cytogenetics. 1993 ; 67 (2) : 81-89.
    PMID 8330276
     
    Congenital abnormalities in children with acute leukemia: a report from the Children's Cancer Group.
    Mertens AC, Wen W, Davies SM, Steinbuch M, Buckley JD, Potter JD, Robison LL
    The Journal of pediatrics. 1998 ; 133 (5) : 617-623.
    PMID 9821417
     
    The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. European 11q23 Workshop participants.
    Moorman AV, Hagemeijer A, Charrin C, Rieder H, Secker-Walker LM
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 805-810.
    PMID 9593285
     
    Pediatric myelodysplasia: a study of 68 children and a new prognostic scoring system.
    Passmore SJ, Hann IM, Stiller CA, Ramani P, Swansbury GJ, Gibbons B, Reeves BR, Chessells JM
    Blood. 1995 ; 85 (7) : 1742-1750.
    PMID 7703482
     
    11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.
    Pui CH, Behm FG, Downing JR, Hancock ML, Shurtleff SA, Ribeiro RC, Head DR, Mahmoud HH, Sandlund JT, Furman WL
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1994 ; 12 (5) : 909-915.
    PMID 8164041
     
    An analysis of leukemic cell chromosomal features in infants.
    Pui CH, Raimondi SC, Murphy SB, Ribeiro RC, Kalwinsky DK, Dahl GV, Crist WM, Williams DL
    Blood. 1987 ; 69 (5) : 1289-1293.
    PMID 2952182
     
    Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498.
    Ravindranath Y, Abella E, Krischer JP, Wiley J, Inoue S, Harris M, Chauvenet A, Alvarado CS, Dubowy R, Ritchey AK
    Blood. 1992 ; 80 (9) : 2210-2214.
    PMID 1384797
     
    Cytogenetic features of neonatal leukemias.
    Sansone R, Negri D
    Cancer genetics and cytogenetics. 1992 ; 63 (1) : 56-61.
    PMID 1423228
     
    General Report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997.
    Secker-Walker LM
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 776-778.
    PMID 9593280
     
    Hematological malignancies with t(9;11)(p21-22;q23)--a laboratory and clinical study of 125 cases. European 11q23 Workshop participants.
    Swansbury GJ, Slater R, Bain BJ, Moorman AV, Secker-Walker LM
    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1998 ; 12 (5) : 792-800.
    PMID 9593283
     
    Ultrastructural studies of the megakaryoblastic leukemias of Down syndrome.
    Zipursky A, Christensen H, De Harven E
    Leukemia & lymphoma. 1995 ; 18 (3-4) : 341-347.
    PMID 8535203
     

    Citation

    This paper should be referenced as such :
    Huret, JL
    Infant leukaemias - Congenital leukaemias - Neonatal leukaemias
    Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):89-92.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Anomalies/InfantLeukID1084.html

    External links

    COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
    arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
    arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
    arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
     
     
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