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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
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Lymphoplasmacytic lymphoma

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS

Clinics and Pathology

Disease lymphoplasmacytic lymphoma (LPL) includes most cases of Waldenstrom's macroglobulinemia and consists of a diffuse proliferation of small lymphocytes, plasmacytoid lymphocytes and plasma cells; the typical histologic features of small lymphocytic lymphoma, mantle cell lymphoma and marginal zone lymphoma must be absent
Phenotype / cell stem origin B-cell antigens are positive; whereas CD5 and, usually, CD23 test negative; the cells express surface and cytoplasmic IgM and are IgD-. CD10 is negative, whereas a proportion of cases have faint CD25 and CD11c expression; the postulated normal counterpart is a B-lymphocyte differentiating into an IgM-secreting plasma cell

Cytogenetics

Note the number of cases studied is small and the interpretation of data must take into account possible variability of histologic classification
Cytogenetics Morphological
  • the t(9;14)(p13;q32), fusing the IgH gene with the BSAP (B-cell specific activator protein), also called PAX5, was found in 50% of the cases in a study; this balanced translocation cannot be viewed as specific for this lymphoma, having been reported in rare marginal zone lymphomas and large cell lymphomas.
  • other recurrent anomalies include 14q32 translocations with 8q24 ( t(8;14)(q24;q32)), 18q21 ( t(14;18)(q32;q21)), trisomies of chromosomes 3 ( +3) and 12 ( +12) and an isochromosome 6p ( i(6p))
  • Other genes implicated (Data extracted from papers in the Atlas)

    Genes IGH

    Translocations implicated (Data extracted from papers in the Atlas)

    Bibliography

    t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation.
    Offit K, Parsa NZ, Filippa D, Jhanwar SC, Chaganti RS
    Blood. 1992 ; 80 (10) : 2594-2599.
    PMID 1384792
     
    A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.
    Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC
    Blood. 1994 ; 84 (5) : 1361-1392.
    PMID 8068936
     
    Genetics of small lymphocyte disorders.
    Panayiotidis P, Kotsi P
    Seminars in hematology. 1999 ; 36 (2) : 171-177.
    PMID 10319386
     
    REVIEW articlesautomatic search in PubMed
    Last year articlesautomatic search in PubMed

    Contributor(s)

    Written05-2000Antonio Cuneo, Gian Luigi Castoldi

    Citation

    This paper should be referenced as such :
    Cuneo, A ; Castoldi, GL
    Lymphoplasmacytic lymphoma
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(2):85-85.
    Free journal version : [ pdf ]   [ DOI ]
    URL : http://AtlasGeneticsOncology.org/Anomalies/LPLID2074.html

    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Tue Feb 17 18:58:30 CET 2015


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