Mantle cell lymphoma

2017-12-01   Ding-Bao Chen 

1.Department of Pathology, Peking University Peoples Hospital, Beijing 100044, Peoples Republic of China;
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France


Mantle cell lymphoma (MCL) is a B-cell neoplasm that usually carries the t(11;14)(q13;q32) translocation and constitutively overexpresses cyclin D1. The clinical evolution is relatively aggressive with a poor response to conventional therapeutic regimens, frequent relapses and a median overall survival of 3-5 years. MCL has a wide spectrum of growth patterns. Most cases have a vaguely nodular and/or diffuse growth pattern, very rare cases have a follicular growth pattern, and a larger minority has a mantle zone growth pattern in which the lymphoma grows as an expanded ring around reactive germinal centers. "In situ MCL" is considered as a very early stage of MCL or even a pre-neoplastic state, and thought to be the tissue equivalent of clonal circulating cells carrying the genetic alterations found in their overt counterpart lymphomas. The impact of some of the newer therapeutic approaches remains to be established.

Clinics and Pathology


Mantle cell lymphoma (MCL) is a B-cell neoplasm generally composed of monomorphic small to medium-sized lymphoid cells with irregular nulear contours and a CCND1 translocation (Swerdlow, et al ,2008. Swerdlow, et al, 2016).
In situ MCL is considered as a very early stage of MCL or even a pre-neoplastic state, and thought to be the tissue equivalent of clonal circulating cells carrying the genetic alterations found in their overt counterpart lymphomas. These are mainly incidental findings, and are defined as lesions that remain compartmentalized (germinal centre/mantle zone) without altering the normal/reactive lymph node (LN) architecture. (Hsu, et al. 2014. Cortelazzo, et al. 2012).

Phenotype stem cell origin

The postulated normal counterpart of MCL is peripheral B-cell of inner mantle zone, mostly of naïve pre-germinal center type (Swerdlow, et al ,2008).
MCL expresses CD20, PAX5, CD43, bcl2, and usually positive for CD5, cyclinD1, but there are minority of cases are negative for CD5, cyclinD1. Sox11 can express in cyclinD1 negative cases. Rare MCL are negative for cyclin D1 and the t(11;14) but have an expression profile and other features indistinguishable from conventional MCL, which have a high expression of cyclinD2 or cyclinD3. MCL is negative for CD10 and bcl6 (Swerdlow, et al ,2008. Swerdlow, et al, 2016). Aberrant phenotypes have been described, sometimes in association with blastoid/pleomorphic variants; these variants include negativity for CD5 (12% of cases), and positivity for CD10 (8%), CD23 (21%), bcl-6 (12%), and MUM1 (35%). (Cortelazzo, et al. 2012).


The incidence of MCL is about 3-10% of non-Hodgkin lymphoma. It occurs in middle-aged to older individuals with a median age about 60 and a variably marked male predominance (about 2:1 or greater) (Swerdlow, et al ,2008. Swerdlow, et al, 2016).
Bermudez et al studied a series of 341 consecutive lymph node resection specimens from patients diagnosed with colorectal and breast adenocarcinoma and incidental and isolated MCLIS was found in 2/341 patients(0.59%).( Bermudez, 2016).


Lymph nodes are the most commonly involved site; the spleen and bone marrow, with or without peripheral blood (PB) involvement, are other important sites of disease. Other extranodal sites are frequently involved, including the gastrointestinal tract and Waldeyer ring. Most cases of multiple lymphomatous polyposis represent MCL (Swerdlow, et al ,2008. Swerdlow, et al, 2016).
Atlas Image
Leukemic phase of mantle cell lymphoma. Peripheral blood. Small to medium sized lymphoid cells with slightly to markedly irregular nuclear contour. The nuclei have moderately dispersed chromatin bur inconspicuous nucleoli. From a patient with 46,XX,t(11;14)(q13;q32) - Text and iconography Courtesy Georges Flandrin 2005.


Morphologically, classical MCL is a monomorphic lymphoid proliferation with a vaguely nodular (13%), diffuse (61%), mantle zone (26%) or rarely follicular growth pattern. Most cases are composed of small to medium-sized lymphoid cells with slightly to markedly irregular nuclear contours, most closely resembling centrocytes. The nuclei have at least somewhat dispersed chromatin but conspicuous nucleoli. Hyalinized small vessels and scattered single epithelioid histiocytes are commonly seen. Evaluation of the proliferation fraction either by counting mitotic figures or estimating the proportion of Ki67 positive nuclei is important for prognosis. The proliferation activity may vary in different cases, but it is generally low, with a percentage of Ki-67 positive cells around 15-30%. In blastoid variant there is a high proliferative activity (Ki-67 positive cells > 40%) (Swerdlow, et al ,2008. Swerdlow, et al, 2016. Cortelazzo, et al. 2012).
There are some variants of MCL: blastoid and pleomorphic variant (aggressive), and small cell, marginal zone-like variant.
  • Blastoid variant: loss of a mantle zone growth pattern, increase in nuclear size and mitotic activity, cells resemble lymphoblasts with dispersed chromatin and a high mitotic rate (usually at least 20-30/10HPF).
  • Pleomorphic variant: cells are pleomorphic but many are large with oval to irregular nuclear contours, generally pale cytoplasm and often prominent nucleoli in at least some of the cells.
  • Small cell variant: small round lymphocytes with more clumped chromatin, either admixed or predominant, mimicking a small lymphocytic lymphoma.
  • Marginal zone-like variant: prominent foci of cells with abundant pale cytoplasm resembling marginal zone of monocytoid B-cell mimicking a marginal zone lymphoma; sometimes these paler foci may also resemble proliferation centers of chronic lymphocytic leukaemia/small lymphocytic lymphoma.
  • In situ MCL shows involvement almost exclusively restricted to the inner mantle zones or to narrow mantles, consisting of cyclin D1+ cells typically in the inner mantle zones of follicles in the absence of overt lymphoma. The mantle zones appear normal or only mildly expanded. In many cases, this is an incidental finding, though can be found in the presence of other small B cell lymphomas or overt MCL. In 2016 WHO classification, in situ MCL is renamed as in situ mantle cell neoplasia (ISMN) to distinguish it from overt MCL, and can be considered observation in patients with indolent disease (asymptomatic with low Ki67 or leukemic non-nodal disease) (Lynch, et al. 2017). These cases must be distinguished from mantle cell lymphoma with a mantle zone pattern and overt mantle cell lymphoma because they may not require therapeutic intervention Carvajal-Cuenca, 2012).
    Two subtypes of MCL based on different clinic-pathological features and molecular abnormalities are recognized: classical MCL and leukemic non-nodal MCL.
  • leukemic non-nodal MCL (previously mistaken for CLL) is a distinct variant which is associated with hyper-mutated IGHV, no expression of SOX11, low Ki67, and few or no other molecular abnormalities beyond a t(11;14) translocation. It typically has an indolent clinical course, infrequent peripheral lymphadenopathy, but is commonly associated with splenomegaly, bone marrow, and peripheral blood involvement (limited to blood and bone marrow) (Lynch, et al. 2017. Ondrejka, et al, 2011).
  • Atlas Image
    Figure1.Mantle cell lymphoma. Diffuse architectural effacement can be seen, composed of small to medium-sized lymphoid cells. (HE staining).
    Atlas Image
    Figure 2. Mantle cell lymphoma, blastoid variant. The lymphoid cells are medium in size, resembling lymphoblasts with dispersed chromatin and a high mitotic rate. (HE staining).
    Atlas Image
    Figure 3. The cells are positive for CD20.
    Atlas Image
    Figure 4. The cells are positive for CD5.
    Atlas Image
    Figure 5. The cells are positive for cyclinD1.
    Atlas Image
    Figure 6A. Mantle cell lymphoma, in situ. Morphology reveals a lymph node with multiple reactive-appearing follicles and prominent paracortical hyperplasia (HE staining).
    Atlas Image
    Figure 6B. Higher power view of one reactive-appearing follicles with germinal centers and normal mantle zones(HE staining).
    Atlas Image
    Figure 6C. The mantle zone cells are positive for CD20.
    Atlas Image
    Figure 6D. The cells are positive for CD5 with numerous T-cells in paracortical regions.
    Atlas Image
    Figure 6E. The cells are positive for cyclin D1 highlighting scattered positive cells in mantle zones.
    Atlas Image
    Figure 6F. The proliferation index of Ki67 is low in mantle zone cells.


    MCL has a median survival of 3-5 years with a short remission duration to standard therapies, but the vast majority of patients cannot be cured. The impact of some of the newer therapeutic approaches remains to be established. (Swerdlow, et al ,2008. Swerdlow, et al, 2016). For selected indolent (either low tumor burden/low proliferative index nodal form or leukemic non-nodal form are often asymptomatic and can be observed with favorable long-term outcomes), low MIPI MCL patients, initial observation may be appropriate therapy. For younger patients with intermediate or high risk MIPI MCL, aggressive therapy with a cytarabine containing regimen autologous stem cell transplantation should be considered. For older MCL patients with intermediate or high risk MIPI, combination chemotherapy with R-CHOP, R-Bendamustine, or a clinical trial should be considered. At the time of relapse, agents directed at activated pathways in MCL cells such as bortezomib (NFkB inhibitor), BTK inhibitors or CAL-101 (B-cell receptor inhibitors) or lenalidamide (anti-angiogenesis) have clinical activity in MCL patients. Autologous or allogeneic stem cell transplantation can also be considered in young patients. (Vose, 2012. Vose, 2015. Vose, 2017).
    It is important to recognize that ISMN does not represent a lymphoma diagnosis and no additional evaluation or therapy is warranted. (Lynch, et al. 2017)
    MCL is heterogeneous a disease, and so are the people that have it; although guidelines are appropriate, therapeutic approaches must be individualized based on a variety of factors and need for personalized therapy to ensure optimal outcomes..(Martin, et al. 2017. Sandoval-Sus, et al.2017). Targeted strategies include the proteasome inhibitors, immune modulatory drugs (IMiDs), mammalian target of rapamycin (mTOR) inhibitors and especially inhibitors of the B-cell receptor pathway (Dreyling, 2015). Given the excellent OS rates regardless of initial therapy in patients with early-stage MCL, de-intensified therapy to limit treatment-related toxicity is a reasonable approach (Dabaja, 2017).


    The most consistently reported adverse histopathological prognostic parameter is a high mitotic rate. A high proliferation index of Ki67 is an adverse prognostic indicator. Some studies reported adverse prognostic features includes: blstoid/pleomorphic morphology, trisomy 12, karyotypic complexity, TP53 mutation/overexpression/loss and overt PB involvement, gains of chromosome 3q and deletions of 9q. The small cell variant and in situ MCL appear to have better course. (Swerdlow, et al ,2008. Swerdlow, et al, 2016). The absence of SOX-11 or a low Ki-67 may correlate with a more indolent form of MCL. The MCL international prognostic index (MIPI) is the prognostic model most often used and incorporates ECOG performance status, age, leukocyte count, and lactic dehydrogenase. A modification of the MIPI also adds the Ki-67 proliferative index if available (Vose, 2012. Vose, 2015. Vose, 2017). The use of intensive frontline therapies including rituximab and consolidated by ASCT ameliorates response rate and prolongs progression-free survival, but any impact on survival remains to be proven. The development of targeted therapies as the consequence of better dissection of pathogenetic pathways in MCL might improve the outcome of conventional chemotherapy in most patients and spare the toxicity of intense therapy in a minority of MCL patients characterized by a relatively indolent disease (Cortelazzo, et al. 2012).
    The in situ MCL is associated with incidental finding, indolent clinical course and lower tumor burden. .(Hsu, et al. 2014)


    Immunoglobulin genes are rearranged . Variable region genes are unmutated in the majority of the cases, but in 15-40% of the cases, IG genes show somatic hypermutation. The t(11;14)(q13;q32) between IGH and cyclinD1 (CCND1) genes is present in almost all cases and considered the primary genetic event. Inactivating mutations of the ATM gene at 11q22-23 have been detected in 40-75% of MCL.(Swerdlow, et al ,2008. Swerdlow, et al, 2016). MCL represents the lymphoma subtype with the highest number of cytogenetic alterations. Secondary chromosomal aberrations including gains in 3q26(31-50%), 7p21 (16-34%) and 8q24 (16-36%: MYC) as well as losses of 1p 13-p31 (29-52%), 6q23-27 (23-38%), 9p21 (18-31%), 11q22-23 (21-59%), 13q11-q13 (22-55%), 13q14-q34 (43-51%) and 17p13pter (21-45%) has been reported. Trisomy 12 was found in 25% of cases. (Cortelazzo, et al. 2012). One study identified a functional LINC-ROR (lncRNA ROR-AS1) involved with regulation of gene transcription via associating with PRC2 complex, and may serve as a novel biomarker in MCL patients. (Hu, et al.2017) There is also improved understanding of the molecular abnormalities seen in MCL, with alterations in ATM, cyclin D1, NOTCH1, and NOTCH2 being more common. (Lynch, et al. 2017).
    The t(11;14) was demonstrated in nine of nine cases with an in situ MCL pattern of cyclin D1-positive cells by conventional cytogenetics of lymph node or peripheral blood samples (3 cases) and/or by FISH studies (8 cases) (Carvajal-Cuenca, 2012).

    Genes Involved and Proteins

    Gene name
    Dna rna description
    5 exons.
    Protein description
    CCND1 binds and activates the G1 cyclin dependent kinases, CDK4 and CDK6. CDK-cyclin D complex phosphorylates members of the retinoblastoma protein family. Regulates the G1/S transition in the cell cycle. Essential for G1 progression. Promotes cellular proliferation and block cell differentiation. Found involved in translocations with fusion genes, amplified and over-expressed, or mutated in a number of cancers.
    Gene name

    Highly cited references

    Pubmed IDYearTitleCitations
    357385512022Comparative evaluation of combined efficacy of methylene blue mediated antimicrobial photodynamic therapy (a-PDT) using 660 nm diode laser versus Erbium-chromium-yttrium-scandium-gallium-garnet (Er, Cr: YSGG) laser as an adjunct to scaling and root planing on clinical parameters in Supportive periodontal therapy: A randomized split-mouth trial.0
    357376642022Assessing the impact of ambient temperature on the risk of hand, foot, and mouth disease in Guangdong, China: New insight from the disease severity and burden.0
    357344672022Positive and Negative Risk-Taking in Adolescence and Early Adulthood: A Citizen Science Study During the COVID-19 Pandemic.0
    357312882022Assessment of hepatic arterial hemodynamics with 4D flow MRI: in vitro analysis of motion and spatial resolution related error and in vivo feasibility study in 20 volunteers.0
    357154462022Perovskite- and Dye-Sensitized Solar-Cell Device Databases Auto-generated Using ChemDataExtractor.0
    357211902022Infusion of Human Albumin on Acute Pancreatitis Therapy: New Tricks for Old Dog?0
    357096972022Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A case control study.0
    357036842022Phenotypic divergence among half-sib progenies of African mahogany.0
    357016272022Validity and reliability of the Arabic version of the Self-Efficacy for Managing Chronic Disease scale in rheumatoid arthritis patients.0
    356995802022Abbreviated Screening MRI for Women with a History of Breast Cancer: Comparison with Full-Protocol Breast MRI.0
    356929502022Performance of the CORB (Confusion, Oxygenation, Respiratory Rate, and Blood Pressure) Scale for the Prediction of Clinical Outcomes in Pneumonia.0
    356908232022High asymptomatic malaria among seasonal migrant workers departing to home from malaria endemic areas in northwest Ethiopia.0
    356888832022Influence of sintering temperatures on microstructure and electrochemical performances of LiNi0.93Co0.04Al0.03O2 cathode for high energy lithium ion batteries.0
    356796332022Massive external validation of a machine learning algorithm to predict pulmonary embolism in hospitalized patients.0
    356611162022Supplemental light application can improve the growth and development of strawberry plants under salinity and alkalinity stress conditions.0
    356484262022Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial.0
    356478932022Outcomes of Restricted versus Liberal Post-Operative Antibiotic Use in Patients Undergoing Appendectomy: A DOOR/RADAR Post Hoc Analysis of the EAST Appendicitis MUSTANG Study.0
    356445952022[Validity and Reliability of a Nursing Process Scale].0
    356404072022De-sialylated and sialylated IgG anti-dsDNA antibodies respectively worsen and mitigate experimental mouse lupus proteinuria and possible mechanisms.0
    355806732022An integrative assessment of the plastic debris load in the Mediterranean Sea.1
    355232982022Estimation of high spatial resolution ground-level ozone concentrations based on Landsat 8 TIR bands with deep forest model.0
    355026822022Radio frequency pasteurization and heating uniformity of canned pineapple.0
    354665462022All-Inorganic Manganese-Based CsMnCl3 Nanocrystals for X-Ray Imaging.0
    354611422022Well entrapped platinum-iron nanoparticles on three-dimensional nitrogen-doped ordered mesoporous carbon as highly efficient and durable catalyst for oxygen reduction and zinc-air battery.0
    354279232022A stacked regression ensemble approach for the quantitative determination of biomass feedstock compositions using near infrared spectroscopy.0
    354265132022Serum Oncomarkers in Patients with MPO-ANCA-Positive Vasculitis: Diagnostic and Prognostic Predictive Values for Interstitial Lung Disease.0
    354222552022Pulmonary nodule malignancy probability: a diagnostic accuracy meta-analysis of the Mayo model.0
    354126942022Heavy Atom-Free, Mitochondria-Targeted, and Activatable Photosensitizers for Photodynamic Therapy with Real-Time In-Situ Therapeutic Monitoring.0
    353676182022Is a single session of antimicrobial photodynamic therapy as an adjuvant to non-surgical scaling and root planing effective in reducing periodontal inflammation and subgingival presence of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in patients with periodontitis?0
    353673862022Enhancing effect of chitosan on methylene blue-mediated photodynamic therapy against C. albicans: A study in planktonic growth, biofilms, and persister cells.0
    353062112022Histological evaluation of skin lesions induced by Leishmania braziliensis treated by PACT using Laser light and 1.9 dimethyl-methylene blue.0
    353011512022Interleukin-18 signaling system links to agitation in severe mental disorders.0
    352359582022Indication Creep of Antenatal Late Preterm Steroids.0
    352189842022Learning from errors: Exploration of the monitoring learning effect.0
    352170162022Endoscopic submucosal dissection for removal of large colorectal neoplasias in an outpatient setting: a single-center series of 660 procedures in Sweden.0
    352130902022Redirection of acyl donor metabolic flux for lipopeptide A40926B0 biosynthesis.0
    352029462022Corrigendum to "Letter to the editor regarding "miR-660-5p-loaded M2 macrophages-derived exosomes augment hepatocellular carcinoma development through regulating KLF3"" [International Immunopharmacology 106 (2022) 108554].0
    352027802022Winter blanketing practices: An online survey of North American horse owners.0
    351843372022Risk of multiple myeloma and other malignancies among first- and second-degree relatives of patients with multiple myeloma: A population-based study.0
    351698722022Impact of photobiomodulation for oral mucositis on body weight and BMI of patients with head and neck cancer.0
    351679882022In vitro and in vivo evaluation of a chlorin-based photosensitizer KAE® for cancer treatment.0
    350755982022Clinical and radiographic effectiveness of mineral trioxide aggregate (MTA) partial pulpotomy with low power or high power diode laser irradiation in deciduous molars: a randomized clinical trial.0
    350608112022Detection of ectopic pregnancy and serum beta hCG levels in women undergoing very early medical abortion: a retrospective cohort study.0
    348551202022A case report of a rapid development of fetal anasarca in a canine pregnancy at term.0
    348117692022Detection of antibodies against influenza D virus in swine veterinarians in Italy in 2004.3
    347384952022Construction of miRNA-mRNA network in the differentiation of chicken preadipocytes.0
    347343022022Completion of single-incision laparoscopic cholecystectomy using the modified Konyang standard method.0
    346969662022Comparison of Ultrasound-Guided Pecto-intercostal Fascial Block and Transversus Thoracic Muscle Plane Block for Acute Poststernotomy Pain Management After Cardiac Surgery: A Prospective, Randomized, Double-Blind Pilot Study.2
    344805882022Risk factors of surgical mortality in patients with Clostridium difficile colitis. A novel scoring system.1
    344719782022Incidence and risk factors for early gastrojejunostomy anastomotic stricture requiring endoscopic intervention following laparoscopic Roux-en-Y gastric bypass: a MBSAQIP analysis.0
    330443702022Utility of a Shortened Isometric Midthigh Pull Protocol for Assessing Rapid Force Production in Athletes.1
    357333602022Investigating the Impact of Patient-Related Factors on Speech Outcomes at 5 Years of Age in Children With a Cleft Palate.0
    357332142022Fabrication of methylene blue-loaded ovalbumin/polypyrrole nanoparticles for enhanced phototherapy-triggered antitumour immune activation.0
    357282992022Perceptions and predictors of respectful maternity care in Malawi: A quantitative cross-sectional analysis.0
    357228342022Morphological and gonadal histological characteristics of silver-phase male Indo-Pacific eel Anguilla marmorata.0
    357224812022Consequences of Social Distancing Measures During the COVID-19 Pandemic First Wave on the Epidemiology of Children Admitted to Pediatric Emergency Departments and Pediatric Intensive Care Units: A Systematic Review.0
    357185672022Hospital service use following an injury hospitalisation for young males and females in a population-level matched retrospective cohort study.0
    357137452022Natural Stibnite for Lithium-/Sodium-Ion Batteries: Carbon Dots Evoked High Initial Coulombic Efficiency.0
    357060382022Association of metabolic syndrome with TyG index and TyG-related parameters in an urban Chinese population: a 15-year prospective study.0
    357041382022A FRET Fluorescent Sensor for Ratiometric and Visual Detection of Sulfide Based on Carbon Dots and Silver Nanoclusters.0
    357015022022Mediating effect of self-esteem on the relationship between leisure experience and aggression.0
    356983082022Structural alterations in cell organelles induced by photodynamic treatment with chlorin p6 -histamine conjugate in human oral carcinoma cells probed by 3D fluorescence microscopy.0
    356917182022The efficacy of different treatments for type 2 cesarean scar pregnancy.0
    356907462022One-year follow-up healthcare costs of patients diagnosed with skin cancer in Germany: a claims data analysis.0
    356903242022Ozone-induced retinal vascular reactivity as assessed by optical coherence tomography angiography.0
    356872592022Evaluation of the Acceptance Rate of Covid-19 Vaccine and its Associated Factors: A Systematic Review and Meta-analysis.0
    356805582022Photothermal Catalytic Oxidation of Cinnamyl Alcohol with Hydrogen Peroxide by Gold Nanoparticle/Antimony-Doped Tin Oxide Nanocrystals.0
    356795782022Ultrafast Intermolecular Interaction Dynamics between NIR-Absorbing Unsymmetrical Squaraines and PCBM: Effects of Halogen Substitution.0
    356767042022Factors associated with low back pain in patients with lumbar spinal stenosis: a cross-sectional study.0
    356765262022Glycemic control and its associated factors in type 2 diabetes patients at Felege Hiwot and Debre Markos Referral Hospitals.0
    356680422022Dupilumab in children with moderate-to-severe asthma: A cost utility analysis.0
    356665562022Outpatient Care Among Users and Nonusers of Direct-to-Patient Telehealth: Observational Study.0
    356618962022A prolonged bout of running increases hepcidin and decreases dietary iron absorption in trained female and male runners.0
    356479412022A nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment.0
    356336092022Copper(II) based low molecular weight collagen fragments-chlorin e6 nanoparticles synergize anti-cancer and anti-bacteria photodynamic therapy.0
    356185382022Biomechanical evaluation of combined proximal tibial osteotomy for varus knee osteoarthritis implanted novel designed plate system: Finite element analysis.0
    356169172022Surfactant-Free Green Synthesis of Au@Chlorophyll Nanorods for NIR PDT-Elicited CDT in Bladder Cancer Therapy.0
    355806982022Melanoma spheroid-containing artificial dermis as an alternative approach to in vivo models.0
    355801742022Spray-Coating Thick Films of All-Inorganic Halide Perovskites for Filterless Narrowband Photodetectors.0
    355374882022First influenza D virus full-genome sequence retrieved from livestock in Namibia, Africa.0
    355221242022Th1, Th2, and Th17 cells are dysregulated, but only Th17 cells relate to C-reactive protein, D-dimer, and mortality risk in Stanford type A aortic dissection patients.0
    355042782022The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.0
    354684352022Carbon payments can cost-effectively improve logging sustainability in the Amazon.0
    354671232022External validation of two prediction models for adequate bowel preparation in Asia: a prospective study.0
    354617202022Test Characteristics of Chest Ultrasonography for Rib Fractures Following Blunt Chest Trauma: A Systematic Review and Meta-analysis.0
    354365762022In vitro study on the effects of photodynamic inactivation using methyl pheophorbide a, PhotoMed, PhotoCure, and 660 nm diode laser on Candida albicans.0
    353786422022Initiation and tolerance of chemoprevention among women with high-risk breast lesions: the potential of low-dose tamoxifen.0
    353660302022A risk classification model for prioritising the management of quality issues relating to substandard medicines in Singapore.0
    352980782022Dental visits in early life: patterns and barriers among Australian children.0
    352924082022The Relationship Between Preoperative Cervical Sagittal Balance and Clinical Outcome of Acute Traumatic Central Cord Syndrome.0
    352744922022circITCH suppresses cell proliferation and metastasis through miR-660/TFCP2 pathway in melanoma.0
    352489612022Environmental levels of carbaryl impair zebrafish larvae behaviour: The potential role of ADRA2B and HTR2B.0
    352435012022Tricuspid and mitral remodelling in atrial fibrillation: a three-dimensional echocardiographic study.0
    352358372022Plant extract incorporated into glass ionomer cement as a photosensitizing agent for antimicrobial photodynamic therapy on Streptococcus mutans.0
    351895012022Nanoscale hematoporphrin-based frameworks for photo-sono synergistic cancer therapy via utilizing Al(III) as metal nodes rather than heavy metals.0
    351758662022Association between health behaviours and the COVID-19 vaccination: risk compensation among healthcare workers in Taizhou, China.0
    351417812022Differences in the prognostic implication of ground-glass opacity on CT according to pathological nodal status in lung cancers treated with lobectomy or pneumonectomy.0
    351012762022Is mechanical bowel preparation necessary in bariatric surgery?0
    350988402022What might have happened: the impact of interrupting entry of innovative drugs on disease outcomes in the United States.0
    350913302022De novo gonad transcriptome analysis of elongate loach (Leptobotia elongata) provides novel insights into sex-related genes.0


    Pubmed IDLast YearTitleAuthors
    269453392016Incidental and Isolated Follicular Lymphoma In Situ and Mantle Cell Lymphoma In Situ Lack Clinical Significance.Bermudez G et al
    220582032012In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior.Carvajal-Cuenca A et al
    216589682012Mantle cell lymphoma.Cortelazzo S et al
    289110682017Early-stage mantle cell lymphoma: a retrospective analysis from the International Lymphoma Radiation Oncology Group (ILROG).Dabaja BS et al
    250157782015Update on the molecular pathogenesis and targeted approaches of mantle cell lymphoma: summary of the 12th annual conference of the European Mantle Cell Lymphoma Network.Dreyling M et al
    246967212014Mantle cell lymphoma with in situ or mantle zone growth pattern: a study of five cases and review of literature.Hsu P et al
    288618852017Erratum to: Clinical Impact of the 2016 Update to the WHO Lymphoma Classification.Lynch RC et al
    286511172017Mantle cell lymphoma - Current standards of care and future directions.Martin P et al
    215081242011Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis.Ondrejka SL et al
    284042212017Mantle Cell Lymphoma: Contemporary Diagnostic and Treatment Perspectives in the Age of Personalized Medicine.Sandoval-Sus JD et al
    286996672017Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management.Vose JM et al


    Ding-Bao Chen

    Mantle cell lymphoma

    Atlas Genet Cytogenet Oncol Haematol. 2017-12-01

    Online version:

    Historical Card

    1998-05-01 Mantle cell lymphoma by  Jean-Loup Huret 

    Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

    External Links