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t(14;18)(q32;q21) BCL2/IGHG1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2539

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameBCL2
Location 11q13.1
Gene NameIGHG1
Location 14q32.33

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

De novo acute B cell leukemia/lymphoma with t(14;18)
Stamatoullas A, Buchonnet G, Lepretre S, Lenain P, Lenormand B, Duval C, Callat MP, Gaulard P, Bastard C, Tilly H
Leukemia 2000 Nov;14(11):1960-6
PMID 11069032
 
Translocation (14;18)(q32;q21) in acute lymphoblastic leukemia: a study of 12 cases and review of the literature
D'Achille P, Seymour JF, Campbell LJ
Cancer Genet Cytogenet 2006 Nov;171(1):52-6
PMID 17074591
 
A population-based cytogenetic study of adults with acute lymphoblastic leukemia
Moorman AV, Chilton L, Wilkinson J, Ensor HM, Bown N, Proctor SJ
Blood 2010 Jan 14;115(2):206-14
PMID 19897583
 
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA Jr, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Loh ML, Hunger SP, Mullighan CG
Nat Commun 2016 Nov 8;7:13331
PMID 27824051
 
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce CM
Science 1985 Sep 27;229(4720):1390-3
PMID 3929382
 
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM
Science 1984 Nov 30;226(4678):1097-9
PMID 6093263
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(14;18)(q32;q21) BCL2/IGHG1

External links

BCL2 (11q13.1) IGHG1 (14q32.33)

Mitelman databaset(14;18)(q32;q21) [Case List]    t(14;18)(q32;q21) [Transloc-MCList] BCL2/IGHG1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:23:02 CET 2018


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jlhuret@AtlasGeneticsOncology.org.