Cytogenetics Laboratory, Pathology Department, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI USA; amohamed@dmc.org
BCL2 is the milestone of apoptosis-regulatory genes. It contributes to tumorigenesis by blocking programmed cell death as such, promoting cell survival. The aberrant expression of BCL2 gene is strongly associated with resistance to chemotherapy and radiation. This review outlines the structure, function, and role of BCL2 gene in cancer.
NCBI: 596 MIM: 151430 HGNC: 990 Ensembl: ENSG00000171791
dbSNP: 596 ClinVar: 596 TCGA: ENSG00000171791 COSMIC: BCL2
Anwar N Mohamed
BCL2 (B-Cell Leukemia/Lymphoma 2)
Atlas Genet Cytogenet Oncol Haematol. 2017-12-01
Online version: http://atlasgeneticsoncology.org/gene/49/bcl2-(b-cell-leukemia-lymphoma-2)
1998-05-01 BCL2 (B-Cell Leukemia/Lymphoma 2) by Jean-Loup Huret  Affiliation