MCL1 (MCL1 apoptosis regulator, BCL2 family member)

2003-02-01  

Identity

HGNC
MCL1
LOCATION
1q21.2
LOCUSID
4170
ALIAS
BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,Mcl-1,TM,bcl2-L-3,mcl1/EAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4170
MIM: 159552
HGNC: 6943
Ensembl: ENSG00000143384

Variants:

dbSNP: 4170
ClinVar: 4170
TCGA: ENSG00000143384
COSMIC: MCL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143384ENST00000307940Q07820
ENSG00000143384ENST00000369026Q07820
ENSG00000143384ENST00000620947A0A087WT64

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Jak-STAT signaling pathwayKEGGko04630
ApoptosisKEGGhsa04210
Jak-STAT signaling pathwayKEGGhsa04630
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376763782024Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.0
382562132024Mcl-1 Protein and Viral Infections: A Narrative Review.0
386610282024TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.0
376763782024Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.0
382562132024Mcl-1 Protein and Viral Infections: A Narrative Review.0
386610282024TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.0
362264982023Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation.6
362605292023N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts.4
363466912023Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies.6
369187172023Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer.6
371422232023Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1.2
371608972023SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication.9
373495982023MCL1 regulates AML cells metabolism via direct interaction with HK2. Metabolic signature at onset predicts overall survival in AMLs' patients.4
374673442023Myeloid cell leukemia-1 as a candidate prognostic biomarker in cancers: a systematic review and meta-analysis.1
380553412023FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma.1

Citation

Dessen P

MCL1 (MCL1 apoptosis regulator, BCL2 family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41317/mcl1-(mcl1-apoptosis-regulator-bcl2-family-member)