BCL2L2 (BCL2 like 2)

2003-02-01  

Identity

HGNC
BCL2L2
LOCATION
14q11.2
LOCUSID
599
ALIAS
BCL-W,BCL2-L-2,BCLW,PPP1R51
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 599
MIM: 601931
HGNC: 995
Ensembl: ENSG00000129473

Variants:

dbSNP: 599
ClinVar: 599
TCGA: ENSG00000129473
COSMIC: BCL2L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129473ENST00000250405Q92843
ENSG00000129473ENST00000553824G3V3B7
ENSG00000129473ENST00000554635G3V3G8
ENSG00000129473ENST00000556599H0YJC7
ENSG00000129473ENST00000557236G3V4B7
ENSG00000129473ENST00000557579G3V5A9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364419292023MiR-140 promotes the progression of intracranial aneurysms by targeting BCL2L2.3
375679742023BCL-W makes only minor contributions to MYC-driven lymphoma development.0
364419292023MiR-140 promotes the progression of intracranial aneurysms by targeting BCL2L2.3
375679742023BCL-W makes only minor contributions to MYC-driven lymphoma development.0
358947792022Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.5
358947792022Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.5
337442572021Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis.1
337840082021BCL2L2 loss renders -14q renal cancer dependent on BCL2L1 that mediates resistance to tyrosine kinase inhibitors.3
339742362021MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.25
345313772021BCL-W expression associates with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified.2
346201262021Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells.3
337442572021Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis.1
337840082021BCL2L2 loss renders -14q renal cancer dependent on BCL2L1 that mediates resistance to tyrosine kinase inhibitors.3
339742362021MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.25
345313772021BCL-W expression associates with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified.2

Citation

Dessen P

BCL2L2 (BCL2 like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/775/bcl2l2-(bcl2-like-2)