BCL2L2 (BCL2 like 2)

2003-02-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
BCL-W,BCL2-L-2,BCLW,PPP1R51
FUSION GENES

Other Information

Locus ID:

NCBI: 599
MIM: 601931
HGNC: 995
Ensembl: ENSG00000129473

Variants:

dbSNP: 599
ClinVar: 599
TCGA: ENSG00000129473
COSMIC: BCL2L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129473ENST00000250405Q92843
ENSG00000129473ENST00000553824G3V3B7
ENSG00000129473ENST00000554635G3V3G8
ENSG00000129473ENST00000556599H0YJC7
ENSG00000129473ENST00000557236G3V4B7
ENSG00000129473ENST00000557579G3V5A9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
270489132016Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.128
186924842008miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196540032009MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer.78
218223012012MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1.76
233378792013MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells.51
126601572003The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity.48
126518472003Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix.29
219473052012miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w.27
235265682015MicroRNA-195 chemosensitizes colon cancer cells to the chemotherapeutic drug doxorubicin by targeting the first binding site of BCL2L2 mRNA.26

Citation

Dessen P

BCL2L2 (BCL2 like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/775/bcl2l2-(bcl2-like-2)