| Written | 2001-01 | Antonio Cuneo, Gianluigi Castoldi |
| Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 2020 |
 | |
| del(11q) del(11q) G- banding (the 3 left partial karyotypes) - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap UW Cytogenetic Services; R-banding (right) – Jean Loup Huret: del(11)(q21) and ATM deletion – Courtesy Hossein Mossafa | |
| Clinics and Pathology |
| Disease | the overall incidence in NHL is 4-5%, the highest incidence having been reported in mantle cell lymphoma, where up to 70% of the cases studied by FISH may harbour a cryptic deletion in association with the classical t(11;14) translocation; FISH detects an approximate 10% incidence of 11q deletion among other histologic subsets of B-NHL; among diffuse large B-cell lymphoma the 11q- chromosome shows a preferential association with the immunoblastic variant; sensitive molecular cytogenetic methods may show 50-70% of T-cell prolymphocytic leukemia to carry an 11q deletion involving the ATM gene |
| Prognosis | a possible association between 11q-/ATM- and poor prognosis in B-cell NHL was reported |
| Cytogenetics |
| Cytogenetics Morphological | the chromosome 11q deletion occurring in NHL most frequently affects the q22-23 bands; the 11q- anomaly occurs as a secondary change in the majority of cases |
| Cytogenetics Molecular | because the size of the deleted segment may be beyond the resolution power of conventional banding analysis, many cases can only be detected by interphase FISH or other genetic methods using probes targeting the 11q22.3-q23.1 region |
| Genes involved and Proteins |
| Note | the region of minimal deletion was narrowed down to a 2-3 Mb pair segment where the ataxia teleangiectasia ( ATM) gene is located; sequencing studies showed mutation in the remaining ATM allele in a significant fraction of cases |
| Bibliography |
| Correlation of chromosome abnormalities with histologic and immunologic characteristics in non-Hodgkin's lymphoma and adult T cell leukemia-lymphoma. Fifth International Workshop on Chromosomes in Leukemia-Lymphoma. |
| Blood. 1987 ; 70 (5) : 1554-1564. |
| PMID 2889485 |
| Acquired chromosome 11q deletion involving the ataxia teleangiectasia locus in B-cell non-Hodgkin's lymphoma: correlation with clinicobiologic features. |
| Cuneo A, Bigoni R, Rigolin GM, Roberti MG, Milani R, Bardi A, Minotto C, Agostini P, De Angeli C, Narducci MG, Sabbioni S, Russo G, Negrini M, Castoldi G |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 ; 18 (13) : 2607-2614. |
| PMID 10893293 |
| Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group. |
| Schlegelberger B, Zwingers T, Harder L, Nowotny H, Siebert R, Vesely M, Bartels H, Sonnen R, Hopfinger G, Nader A, Ott G, Müller-Hermelink K, Feller A, Heinz R |
| Blood. 1999 ; 94 (9) : 3114-3120. |
| PMID 10556197 |
| Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. |
| Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, Möller P, Müller-Hermelink HK, James MR, Lichter P, Döhner H |
| Blood. 1999 ; 94 (9) : 3262-3264. |
| PMID 10556216 |
| Inactivation of the ATM gene in T-cell prolymphocytic leukemias. |
| Stoppa-Lyonnet D, Soulier J, Laugé A, Dastot H, Garand R, Sigaux F, Stern MH |
| Blood. 1998 ; 91 (10) : 3920-3926. |
| PMID 9573030 |
| Chromosome 11q rearrangements in B non Hodgkin's lymphoma. |
| Vandenberghe E, De Wolf Peeters C, Wlodarska I, Stul M, Louwagie A, Verhoef G, Thomas J, Criel A, Cassiman JJ, Mecucci C |
| British journal of haematology. 1992 ; 81 (2) : 212-217. |
| PMID 1643018 |
| Citation |
| This paper should be referenced as such : |
| Cuneo, A ; Castoldi, GL |
| del(11q) in non-Hodgkin's lymphoma (NHL) |
| Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):50-51. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/del11qNHLID2020.html |
| Other genes implicated (Data extracted from papers in the Atlas) [ 1 ] |
| Genes | CD38 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| del(11q) in non-Hodgkin's lymphoma (NHL) | |
| External links |
| Mitelman database | del(11q) |
| arrayMap (UZH-SIB Zurich) | [select an item] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Sep 7 15:06:22 CEST 2020 |
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