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del(11q) in non-Hodgkin's lymphoma (NHL)

Written2001-01Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

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Atlas_Id 2020
  del(11q)   del(11q) G- banding (the 3 left partial karyotypes) - Courtesy Diane H. Norback, Eric B. Johnson, Sara Morrison-Delap UW Cytogenetic Services; R-banding (right) – Jean Loup Huret: del(11)(q21) and ATM deletion – Courtesy Hossein Mossafa

Clinics and Pathology

Disease the overall incidence in NHL is 4-5%, the highest incidence having been reported in mantle cell lymphoma, where up to 70% of the cases studied by FISH may harbour a cryptic deletion in association with the classical t(11;14) translocation; FISH detects an approximate 10% incidence of 11q deletion among other histologic subsets of B-NHL; among diffuse large B-cell lymphoma the 11q- chromosome shows a preferential association with the immunoblastic variant; sensitive molecular cytogenetic methods may show 50-70% of T-cell prolymphocytic leukemia to carry an 11q deletion involving the ATM gene
Prognosis a possible association between 11q-/ATM- and poor prognosis in B-cell NHL was reported


Cytogenetics Morphological the chromosome 11q deletion occurring in NHL most frequently affects the q22-23 bands; the 11q- anomaly occurs as a secondary change in the majority of cases
Cytogenetics Molecular because the size of the deleted segment may be beyond the resolution power of conventional banding analysis, many cases can only be detected by interphase FISH or other genetic methods using probes targeting the 11q22.3-q23.1 region

Genes involved and Proteins

Note the region of minimal deletion was narrowed down to a 2-3 Mb pair segment where the ataxia teleangiectasia ( ATM) gene is located; sequencing studies showed mutation in the remaining ATM allele in a significant fraction of cases


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PMID 2889485
Acquired chromosome 11q deletion involving the ataxia teleangiectasia locus in B-cell non-Hodgkin's lymphoma: correlation with clinicobiologic features.
Cuneo A, Bigoni R, Rigolin GM, Roberti MG, Milani R, Bardi A, Minotto C, Agostini P, De Angeli C, Narducci MG, Sabbioni S, Russo G, Negrini M, Castoldi G
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 ; 18 (13) : 2607-2614.
PMID 10893293
Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group.
Schlegelberger B, Zwingers T, Harder L, Nowotny H, Siebert R, Vesely M, Bartels H, Sonnen R, Hopfinger G, Nader A, Ott G, Müller-Hermelink K, Feller A, Heinz R
Blood. 1999 ; 94 (9) : 3114-3120.
PMID 10556197
Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma.
Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, Möller P, Müller-Hermelink HK, James MR, Lichter P, Döhner H
Blood. 1999 ; 94 (9) : 3262-3264.
PMID 10556216
Inactivation of the ATM gene in T-cell prolymphocytic leukemias.
Stoppa-Lyonnet D, Soulier J, Laugé A, Dastot H, Garand R, Sigaux F, Stern MH
Blood. 1998 ; 91 (10) : 3920-3926.
PMID 9573030
Chromosome 11q rearrangements in B non Hodgkin's lymphoma.
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PMID 1643018


This paper should be referenced as such :
Cuneo, A ; Castoldi, GL
del(11q) in non-Hodgkin's lymphoma (NHL)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):50-51.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes ATM CD38

Translocations implicated (Data extracted from papers in the Atlas)

 del(11q) in non-Hodgkin's lymphoma (NHL)

External links

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