t(1;3)(p36;p21)

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(1;3)(p36;p21)

Clinics and Pathology

Disease	found in various hematological malignancies: 2 chronic myelogenous leukemia (CML), i of which in accelerated phase, 1 myelodysplastic syndrome (MDS) of RAEB type, 2 treatment related MDS, 2 M3- ANLL (acute non lymphocytic leukemia), 2 acute lymphocytic leukemias (ALL), and 1 treatment related ALL, 3 non Hodgkin lymphoma (NHL), (2 follicular and 1 diffuse large cell NHL) . Five patients had a history of a previous treatment for malignancy (alkylating agent in 3 cases).
Epidemiology	only 13 cases to date; 7 to 87 yr old patients, most patients being in the fifties; sex ratio: 7M/6F
Prognosis	very variable survival, from 25 days to 16 yrs+

Genetics

according to the variability in the above data, the t(1;3)(p36;p21) is likely to be heterogeneous also at the molecular level.

Cytogenetics

Cytogenetics Morphological

t(1;3)(p36;p21) is part of a complex karyotype in 12 of the 13 cases, and it appears to be a secondary anomaly: accompanying t(9;22)(q34;q11) in CML, t(15;17)(q22;q21) in M3 ANLL, -7 in t-MDS, t(14;18)(q32;q21) in follicular NHL, and also del(6q) in 3 cases and various non recurrent anomalies. In 2 cases, the der(1) appears the crucial event: a complex t(1;2;3) in M3 ANLL, where 3p21->pter is translocated onto der(1), and a der(1) without der(3) t(1;3) in NHL

External links

Other database	t(1;3)(p36;p21)	Mitelman database (CGAP - NCBI)
Other database	t(1;3)(p36;p21)	CancerChromosomes (NCBI)

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity, especially so, since it looks quite heterogeneous:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Cytogenetic analysis of chimerism and leukemia relapse in chronic myelogenous leukemia patients after T cell-depleted bone marrow transplantation.

Offit K, Burns JP, Cunningham I, Jhanwar SC, Black P, Kernan NA, O'Reilly RJ, Chaganti RS

Blood. 1990 ; 75 (6) : 1346-1355.

Sequential analysis of 43 patients with non-Hodgkin's lymphoma: clinical correlations with cytogenetic, histologic, immunophenotyping, and molecular studies.

Whang-Peng J, Knutsen T, Jaffe ES, Steinberg SM, Raffeld M, Zhao WP, Duffey P, Condron K, Yano T, Longo DL

Blood. 1995 ; 85 (1) : 203-216.

3p21 is a recurrent treatment-related breakpoint in myelodysplastic syndrome and acute myeloid leukemia.

Shi G, Weh HJ, Martensen S, Seeger D, Hossfeld DK

Cytogenetics and cell genetics. 1996 ; 74 (4) : 295-299.

Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18).

Horsman DE, Connors JM, Pantzar T, Gascoyne RD

Genes, chromosomes & cancer. 2001 ; 30 (4) : 375-382.

Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization.

Dave BJ, Nelson M, Pickering DL, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Sanger WG

Cancer genetics and cytogenetics. 2002 ; 132 (2) : 125-132.

t(1;3)(p36;p21) is a recurring therapy-related translocation.

Sato Y, Izumi T, Kanamori H, Davis EM, Miura Y, Larson RA, Le Beau MM, Ozawa K, Rowley JD

Genes, chromosomes & cancer. 2002 ; 34 (2) : 186-192.

Contributor(s)

Written	05-2002	Jean-Loup Huret

This paper should be referenced as such :

Huret JL . t(1;3)(p36;p21). Atlas Genet Cytogenet Oncol Haematol. May 2002 .
URL : http://AtlasGeneticsOncology.org/Anomalies/t0103p36p21ID1237.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 6 15:45:25 CET 2010

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.