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Written2002-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1237

Clinics and Pathology

Disease found in various hematological malignancies: 2 chronic myelogenous leukemia (CML), 1 of which in accelerated phase, 1 myelodysplastic syndrome (MDS) of RAEB type, 2 treatment related MDS, 2 M3- AML (acute myeloid leukemia), 2 acute lymphocytic leukemias (ALL), and 1 treatment related ALL, 3 non Hodgkin lymphoma (NHL), (2 follicular and 1 diffuse large cell NHL) . Five patients had a history of a previous treatment for malignancy (alkylating agent in 3 cases).
Epidemiology only 13 cases to date; 7 to 87 yr old patients, most patients being in the fifties; sex ratio: 7M/6F
Prognosis very variable survival, from 25 days to 16 yrs+


according to the variability in the above data, the t(1;3)(p36;p21) is likely to be heterogeneous also at the molecular level.


Cytogenetics Morphological t(1;3)(p36;p21) is part of a complex karyotype in 12 of the 13 cases, and it appears to be a secondary anomaly: accompanying t(9;22)(q34;q11) in CML, t(15;17)(q22;q21) in M3 AML, -7 in t-MDS, t(14;18)(q32;q21) in follicular NHL, and also del(6q) in 3 cases and various non recurrent anomalies. In 2 cases, the der(1) appears the crucial event: a complex t(1;2;3) in M3 AML, where 3p21->pter is translocated onto der(1), and a der(1) without der(3) t(1;3) in NHL

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity, especially so, since it looks quite heterogeneous:
you are welcome to submit a paper to our new Case Report section.
Case Report Translocation t(1;3)(p36;p21) and other aberrations in a case of AML secondary to MDS


Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization.
Dave BJ, Nelson M, Pickering DL, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Sanger WG
Cancer genetics and cytogenetics. 2002 ; 132 (2) : 125-132.
PMID 11850073
Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18).
Horsman DE, Connors JM, Pantzar T, Gascoyne RD
Genes, chromosomes & cancer. 2001 ; 30 (4) : 375-382.
PMID 11241790
Cytogenetic analysis of chimerism and leukemia relapse in chronic myelogenous leukemia patients after T cell-depleted bone marrow transplantation.
Offit K, Burns JP, Cunningham I, Jhanwar SC, Black P, Kernan NA, O'Reilly RJ, Chaganti RS
Blood. 1990 ; 75 (6) : 1346-1355.
PMID 2310831
t(1;3)(p36;p21) is a recurring therapy-related translocation.
Sato Y, Izumi T, Kanamori H, Davis EM, Miura Y, Larson RA, Le Beau MM, Ozawa K, Rowley JD
Genes, chromosomes & cancer. 2002 ; 34 (2) : 186-192.
PMID 11979552
3p21 is a recurrent treatment-related breakpoint in myelodysplastic syndrome and acute myeloid leukemia.
Shi G, Weh HJ, Martensen S, Seeger D, Hossfeld DK
Cytogenetics and cell genetics. 1996 ; 74 (4) : 295-299.
PMID 8976389
Sequential analysis of 43 patients with non-Hodgkin's lymphoma: clinical correlations with cytogenetic, histologic, immunophenotyping, and molecular studies.
Whang-Peng J, Knutsen T, Jaffe ES, Steinberg SM, Raffeld M, Zhao WP, Duffey P, Condron K, Yano T, Longo DL
Blood. 1995 ; 85 (1) : 203-216.
PMID 7803794


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2002;6(3):229-229.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(1;3)(p36;p21)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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