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t(1;5)(p32;q31) ?::TAL1

Written1998-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
Atlas_Id 1141

Clinics and Pathology

Disease T cell acute lymphocytic leukaemia (T-ALL)
Clinics yet poorly known: only 1 case: a young adult male patient with high WBC (common features in T-ALL); bone marrow transplantation; complete remission: 43 mths +

Genes involved and Proteins

Gene NameTAL1 (T-cell acute leukemia 1)
Location 1p33
Dna / Rna complex alternate splicing
Protein contains a basic Helix-Loop-Helix (DNA binding) domain; forms heterodimers; transcription factor; role in haematopoietic cell differentiation
Gene Nameyet unknown gene
Location 5q31

Result of the chromosomal anomaly

Hybrid gene
Description breakpoint on TAL1 was found 10kb upstream the gene, as was found in the cases of t(1;3)(p32;p21), while it is more 3', within the gene, in the t(1;14)(p32;q11) and in TAL1 deletions.
Fusion Protein
Expression Localisation high nuclear expression

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia.
François S, Delabesse E, Baranger L, Dautel M, Foussard C, Boasson M, Blanchet O, Bernard O, Macintyre EA, Ifrah N
Genes, chromosomes & cancer. 1998 ; 23 (1) : 36-43.
PMID 9713995


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 1999;3(1):21-21.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;5)(p32;q31) ?/TAL1

External links

Mitelman databaset(1;5)(p32;q31)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9837/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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