TAL1 (T-cell acute leukemia 1)

1998-03-01 Marie-Claude Labastie , Jean-Loup Huret Affiliation

Institut dEmbryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France

Identity

HGNC

TAL1

LOCATION

1p33

LOCUSID

6886

ALIAS

SCL,TCL5,bHLHa17,tal-1

FUSION GENES

Show Gene Fusions

DNA/RNA

DNA diagram

Description

8 exons; 16 kb; SIL (a different gene) sits 90 kb further in 5

Transcription

(complex) alternate splicing of: 1A with 2A, or 3 vs 1B, 2B,3 ...or directly 4, 5, 6

Proteins

Description

331 amino acids for the major form of 48 KDa; a truncated form of 26 KDa only in some T-ALL; domains: prolin rich in N-trem; poly Gly; basic Helix-Loop-Helix from the exon 6.

Expression

in hematopoietic stem cells, erythroid and megakaryocytic lineages of the adult and in the embryonic brain; indispensable for the genesis of the hematopoietic system.

Function

transcription factor; exhibits sequence-specific DNA binding activity when in dimers with another bHLH protein such as E2A (DNA specific sequences are: CANNTG, especially: CAGATG); direct interactions of the bHLH with the LIM domain of RBTN2 or RBTN1.

Homology

TAL2 in 9q32; LYL1 in 19p13; more distantly: MYC and other members of the MYC family of Helix-Loop-Helix transcription factors.

Implicated in

Entity name

t(1;7)(p32;q34) or t(1;14)(p32;q11)/T-ALL --> TAL1 - TRB or TAL1 -TRD

Disease

T-cell ALL

Prognosis

is not too poor, compared to other T-ALL

Entity name

T-ALL with normal karyotype, but with submicroscopic deletions of part of TAL1 in the 5 region --> SIL - TAL1

Disease

found in 10 to 30 % of T-ALL with a normal karyotype

Hybrid gene

deletions which place SIL (SCL interrupting sequence) in close 5 of TAL1; hybrid gene with exon 1 from SIL.

Fusion protein

TAL1 is under the promoter sequences controle of SIL, a gene active during T cell development.

Entity name

t(1;3)(p32;p21)/T-ALL --> TAL1 - TCTA

Disease

T-cell ALL

Breakpoints

Note

mainly in 5 in a 1 kb region; but also dispersed in rare cases

Article Bibliography

Pubmed ID	Last Year	Title	Authors
8471769	1993	Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.	Bash RO et al
8760303	1996	The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.	Hofmann TJ et al
9020185	1997	Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.	Ono Y et al
7568177	1995	Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.	Osada H et al
8689686	1996	The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.	Porcher C et al
7957052	1994	Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.	Wadman I et al

Other Information

Locus ID:

NCBI: 6886
MIM: 187040
HGNC: 11556
Ensembl: ENSG00000162367

Variants:

dbSNP: 6886
ClinVar: 6886
TCGA: ENSG00000162367
COSMIC: TAL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162367	ENST00000294339	P17542
ENSG00000162367	ENST00000371884	P17542

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38102337	2024	Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia.	1
38102337	2024	Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia.	1
36632736	2023	TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.	2
36632736	2023	TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.	2
33664368	2021	Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).	9
34075404	2021	Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells.	17
33664368	2021	Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).	9
34075404	2021	Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells.	17
32086528	2020	Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.	12
32593672	2020	The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2.	3
32633635	2020	MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia.	7
32835548	2020	SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome.	4
33177556	2020	Dengue virus infection impedes megakaryopoiesis in MEG-01 cells where the virus envelope protein interacts with the transcription factor TAL-1.	7
33293632	2020	The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis.	5
32086528	2020	Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.	12

Citation

Marie-Claude Labastie ; Jean-Loup Huret

TAL1 (T-cell acute leukemia 1)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/15/tal1-(t-cell-acute-leukemia-1)

Historical Card

1997-08-01 TAL1 (T-cell acute leukemia 1) by Jean-Loup Huret,Marie-Claude Labastie Affiliation

Institut dEmbryologie Cellulaire et Moléculaire, CNRS FRE 216O, 94736, Nogent-sur-Marne Cedex, France