TRB (T cell Receptor Beta)

2000-07-01   Marie-Paule Lefranc 

IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

Identity

HGNC
LOCATION
7q34
IMAGE
Atlas Image
LEGEND
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
LOCUSID
ALIAS
TCRB,TRB@

DNA/RNA

Atlas Image
TRB
V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
TRB
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene.
for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Description

  • The human TRB locus at 7q35 spans 620 kb. It consists of 64-67 TRBV genes belonging to 32 subgroups.
  • Except for TRBV30, localized downstream of the TRBC2 gene, in inverted orientation of transcription, all the other TRBV genes are located upstream of a duplicated D-J-C-cluster, which comprises, for the first part one TRBD, six TRBJ, and the TRBC1 gene, and for the second part, one TRBD, eight TRBJ, and the TRBC2 gene.
  • The most 5 TRBV genes occupy the most centromeric position, whereas the TRBV30 gene, 3 of the locus, is the most telomeric gene in the TRB locus.
  • The potentiel repertoire consists of 39-46 functional TRBV genes belonging to 21-23 subgroups, the two TRBD, thirteen TRBJ (6 from the first cluster and 7 from the second cluster), and the two TRBC genes.
  • Six TRBV orphons have been localized on chromosome 9 at 9p21. Enhancer sequences have been characterized 5.5kb 3 from TRBC2.
  • List of the human TRB genes
  • Mutations

    Note

    Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity name
    Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(1;7)(p32;q35); involve TRB - TAL1 in 1p32
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Prognosis
    median survival > 5 yrs in children
    Entity name
    t(7;9)(q35;q32); involve TRB - TAL2 in 9q32
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(7;9)(q35;q34); involve TRB - TAN1 in 9q34
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(7;10)(q35;q24); involve TRB - HOX11 in 10q24
    Disease
    T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
    Prognosis
    not unfavourable
    Entity name
    t(7;11)(q35;p13); involve TRB - RBTN2 in 11p13
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(7;14)(q35;q32); involve TRB - TCL1 in 14q32
    Disease
    T-cell lymphoproliferations
    Entity name
    t(7;19)(q35;p13); involve TRB - LYL1 in 19p13
    Disease
    T-cell acute lymphoblastic leukemia (ALL)

    Breakpoints

    Atlas Image

    Other Information

    Locus ID:

    NCBI: 6957
    HGNC: 12155

    Variants:

    dbSNP: 6957
    ClinVar: 6957
    COSMIC: TRB

    References

    Pubmed IDYearTitleCitations
    197068842009Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.390
    213832442011A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing.79
    169688992007Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex.59
    182758292008The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.56
    183787922008A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.46
    238782182013Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.46
    216733452011Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.39
    254224322014Molecular architecture of the αβ T cell receptor-CD3 complex.37
    230910592012Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering.35
    190566902009An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.33

    Citation

    Marie-Paule Lefranc

    TRB (T cell Receptor Beta)

    Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

    Online version: http://atlasgeneticsoncology.org/gene/24/trb-(t-cell-receptor-beta)