TLX1 (T cell leukemia homeobox 1)

2003-02-01  

Identity

HGNC
LOCATION
10q24.31
LOCUSID
ALIAS
HOX11,TCL3
FUSION GENES

Other Information

Locus ID:

NCBI: 3195
MIM: 186770
HGNC: 5056
Ensembl: ENSG00000107807

Variants:

dbSNP: 3195
ClinVar: 3195
TCGA: ENSG00000107807
COSMIC: TLX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107807ENST00000370196P31314
ENSG00000107807ENST00000463716G3V1B7
ENSG00000107807ENST00000467928P31314

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

References

Pubmed IDYearTitleCitations
324888802020Association of TLX1 gene polymorphisms with the risk of acute lymphoblastic leukemia and B lineage acute lymphoblastic leukemia in Han Chinese children.1
324888802020Association of TLX1 gene polymorphisms with the risk of acute lymphoblastic leukemia and B lineage acute lymphoblastic leukemia in Han Chinese children.1
295559752018Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.16
299549332018A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing.10
301071772018Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.31
295559752018Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.16
299549332018A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing.10
301071772018Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.31
283513982017Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer.24
286744222017Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.10
283513982017Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer.24
286744222017Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.10
240017732013G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.23
240017732013G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.23
223669492012Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.80

Citation

Dessen P

TLX1 (T cell leukemia homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/31/tlx1-(t-cell-leukemia-homeobox-1)