TCL1A (T-cell leukemia/lymphoma 1A)

1998-03-01   Marc-Henri Stern  

Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France

Identity

HGNC
LOCATION
14q32.13
LOCUSID
ALIAS
TCL1
FUSION GENES

DNA/RNA

Description

4 exons; telomere - exon 1 to 4 - centromere orientation

Transcription

1.3 kb transcripts

Proteins

Description

114 amino acids; one domain with a b-barrel topology

Expression

immature T and B lymphoid cells

Localisation

cytoplasm

Function

unknown

Homology

MTCP1 (38 % identity, similar tridimentional structure)

Implicated in

Entity name
t(14;14)(q12;q32.1) or inv(14)(q12q32.1) /T-cell malignancies --> TCRA/D - TCL1A
Disease
mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL
Cytogenetics
associated with i(8q) in T-PLL
Hybrid gene
none
Fusion protein
none
Oncogenesis
over expression of TCL1 is considered as critical in the oncogenetic mechanism
Entity name
t(7;14)(q35;q32.1)/T-cell malignancies --> TCRB - TCL1A
Cytogenetics
associated with i(8q)
Hybrid gene
none
Fusion protein
none
Oncogenesis
over expression of TCL1

Article Bibliography

Pubmed IDLast YearTitleAuthors
79878161994Characterization and localization of the TCL-1 oncogene product.Fu TB et al
95194061998Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.Hoh F et al
92856871997The murine Tcl1 oncogene: embryonic and lymphoid cell expression.Narducci MG et al
85702151996Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.Thick J et al
78090721994Identification of the TCL1 gene involved in T-cell malignancies.Virgilio L et al

Other Information

Locus ID:

NCBI: 8115
MIM: 186960
HGNC: 11648
Ensembl: ENSG00000100721

Variants:

dbSNP: 8115
ClinVar: 8115
TCGA: ENSG00000100721
COSMIC: TCL1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100721ENST00000402399P56279
ENSG00000100721ENST00000402399A0A024R6G5
ENSG00000100721ENST00000554012P56279
ENSG00000100721ENST00000554012A0A024R6G5
ENSG00000100721ENST00000554119G3V4T4
ENSG00000100721ENST00000555202P56279
ENSG00000100721ENST00000555202A0A024R6G5
ENSG00000100721ENST00000555886G3V4T4
ENSG00000100721ENST00000556156G3V4T4
ENSG00000100721ENST00000556450P56279
ENSG00000100721ENST00000556450A0A024R6G5
ENSG00000100721ENST00000557043H0YJR9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363173392023TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.3
370233722023Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.2
370460832023Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.16
363173392023TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.3
370233722023Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.2
370460832023Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.16
337608602021Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.2
342060472021TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.7
337608602021Polymorphisms of T- cell leukemia 1A gene loci are not related to the development of adjuvant letrozole-induced adverse events in breast cancer.2
342060472021TCL1A, B Cell Regulation and Tolerance in Renal Transplantation.7
333010312020Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.13
333010312020Noncanonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.13
290481252018TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.4
294495752018Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.40
295929482018TCL1A, a Novel Transcription Factor and a Coregulator of Nuclear Factor κB p65: Single Nucleotide Polymorphism and Estrogen Dependence.6

Citation

Marc-Henri Stern

TCL1A (T-cell leukemia/lymphoma 1A)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/66/tcl1a-(t-cell-leukemia-lymphoma-1a)