OLIG2 (oligodendrocyte lineage transcription factor)

2004-05-01   David Rowitch 

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA

Identity

HGNC
LOCATION
21q22.11
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
BHLHB1,OLIGO2,PRKCBP2,RACK17,bHLHe19
FUSION GENES

DNA/RNA

Note

OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.

Proteins

Description

329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).

Expression

Olig2 is expressed in the ventral thalamus of developing mice.

Function

Required for oligodendrocyte and motor neuron specification in the spinal cord.

Implicated in

Entity name
Cytogenetics
Translocation t(14;21)(q11.2;q22)
Hybrid gene
T-cell receptor promoter translocated upstream of OLIG2.
Fusion protein
none
Entity name
Brain cancer
Disease
Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis
variable
Cytogenetics
No known genetic abnormalities in OLIG2.
Hybrid gene
n/a
Oncogenesis
OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.

Bibliography

Pubmed IDLast YearTitleAuthors
149896032004Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.Azzarelli B et al
119727952002OLIG-1 and 2 gene expression and oligodendroglial tumours.Hoang-Xuan K et al
115262052001Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.Lu QR et al
114982202001OLIG2 as a specific marker of oligodendroglial tumour cells.Marie Y et al
107378012000The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.Wang J et al

Other Information

Locus ID:

NCBI: 10215
MIM: 606386
HGNC: 9398
Ensembl: ENSG00000205927

Variants:

dbSNP: 10215
ClinVar: 10215
TCGA: ENSG00000205927
COSMIC: OLIG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205927ENST00000333337Q13516
ENSG00000205927ENST00000382357Q13516
ENSG00000205927ENST00000430860C9J444

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151981282004The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.141
166826442006Development of NG2 neural progenitor cells requires Olig gene function.84
231652592012Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.61
168914212006Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.47
168914212006Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.47
162672132005Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS.46
179641172008Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.41
197726052009Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury.34
216248112011Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells.28
172832882007A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.24

Citation

David Rowitch

OLIG2 (oligodendrocyte lineage transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/236/olig2-(oligodendrocyte-lineage-transcription-factor)