OLIG2 (oligodendrocyte lineage transcription factor)
2004-05-01 David Rowitch AffiliationDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Dana 640D, 44 Binney Street, Boston, MA 02115, USA
Identity
HGNC
LOCATION
21q22.11
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
BHLHB1,OLIGO2,PRKCBP2,RACK17,bHLHe19
FUSION GENES
DNA/RNA
Note
OLIG2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development.
Proteins
Description
329 amino acids; 32 kDa; contains 1 basic helix-loop-helix DNA-binding domain (bHLH).
Expression
Olig2 is expressed in the ventral thalamus of developing mice.
Function
Required for oligodendrocyte and motor neuron specification in the spinal cord.
Implicated in
Entity name
Cytogenetics
Translocation t(14;21)(q11.2;q22)
Hybrid gene
T-cell receptor promoter translocated upstream of OLIG2.
Fusion protein
none
Entity name
Brain cancer
Disease
Oligodendroglioma, astrocytoma, glioblastoma.
Prognosis
variable
Cytogenetics
No known genetic abnormalities in OLIG2.
Hybrid gene
n/a
Oncogenesis
OLIG expression in brain cancer raises possibilities that it could regulate behavior of tumor cell populations but this has not been demonstrated.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 14989603 | 2004 | Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. | Azzarelli B et al |
| 11972795 | 2002 | OLIG-1 and 2 gene expression and oligodendroglial tumours. | Hoang-Xuan K et al |
| 11526205 | 2001 | Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. | Lu QR et al |
| 11498220 | 2001 | OLIG2 as a specific marker of oligodendroglial tumour cells. | Marie Y et al |
| 10737801 | 2000 | The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. | Wang J et al |
Other Information
Locus ID:
NCBI: 10215
MIM: 606386
HGNC: 9398
Ensembl: ENSG00000205927
Variants:
dbSNP: 10215
ClinVar: 10215
TCGA: ENSG00000205927
COSMIC: OLIG2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000205927 | ENST00000333337 | Q13516 |
| ENSG00000205927 | ENST00000382357 | Q13516 |
| ENSG00000205927 | ENST00000430860 | C9J444 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37748631 | 2024 | OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking. | 0 |
| 37748631 | 2024 | OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking. | 0 |
| 36193754 | 2023 | Identifying an oligodendrocyte enhancer that regulates Olig2 expression. | 1 |
| 37001387 | 2023 | OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM). | 0 |
| 36193754 | 2023 | Identifying an oligodendrocyte enhancer that regulates Olig2 expression. | 1 |
| 37001387 | 2023 | OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM). | 0 |
| 35132566 | 2022 | The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells. | 0 |
| 35736214 | 2022 | OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma. | 4 |
| 35856894 | 2022 | Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas. | 0 |
| 35967956 | 2022 | Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder. | 0 |
| 35132566 | 2022 | The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells. | 0 |
| 35736214 | 2022 | OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma. | 4 |
| 35856894 | 2022 | Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas. | 0 |
| 35967956 | 2022 | Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder. | 0 |
| 33539525 | 2021 | OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes. | 4 |
Citation
David Rowitch
OLIG2 (oligodendrocyte lineage transcription factor)
Atlas Genet Cytogenet Oncol Haematol. 2004-05-01
Online version: http://atlasgeneticsoncology.org/gene/236/olig2-(oligodendrocyte-lineage-transcription-factor)
