TCTA (T-cell leukemia translocation-associated gene)

1998-03-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
TCTA
LOCATION
3p21.31
LOCUSID
6988
ALIAS
-
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image
DNA diagram

Transcription

2.1 kb mRNA

Proteins

Description

103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61)

Expression

wide, especially in kidneys

Localisation

may be a membrane associated protein, as there is a hydrophobic domain

Function

unknown

Homology

none is known

Implicated in

Entity name
t(1;3)(p32;p21)/T-cell ALL --> TAL1 - TCTA
Disease
T-cell ALL
Hybrid gene
head to head orientation of TAL1 and TCTA
Fusion protein
no fusion protein, but possibly promoter exchange and gene disregulation

Article Bibliography

Pubmed IDLast YearTitleAuthors
77287591995Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.Aplan PD et al

Other Information

Locus ID:

NCBI: 6988
MIM: 600690
HGNC: 11692
Ensembl: ENSG00000145022

Variants:

dbSNP: 6988
ClinVar: 6988
TCGA: ENSG00000145022
COSMIC: TCTA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145022ENST00000273590P57738

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.30
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.30
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
195605692009T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis.8
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
200460132009[Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis].1
195605692009T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis.8
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
200460132009[Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis].1
221745632004Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism.0
221745632004Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism.0

Citation

Jean-Loup Huret

TCTA (T-cell leukemia translocation-associated gene)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/58/tcta-(t-cell-leukemia-translocation-associated-gene)

Historical Card

1998-01-01 TCTA (T-cell leukemia translocation-associated gene) by  Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France