TCTA (T-cell leukemia translocation-associated gene)

1998-03-01   Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
-
FUSION GENES

DNA/RNA

Atlas Image
DNA diagram

Transcription

2.1 kb mRNA

Proteins

Description

103 amino acids; 11 kDa; rich in hydrophobic amino acids (residues 41-61)

Expression

wide, especially in kidneys

Localisation

may be a membrane associated protein, as there is a hydrophobic domain

Function

unknown

Homology

none is known

Implicated in

Entity name
t(1;3)(p32;p21)/T-cell ALL --> TAL1 - TCTA
Disease
T-cell ALL
Hybrid gene
head to head orientation of TAL1 and TCTA
Fusion protein
no fusion protein, but possibly promoter exchange and gene disregulation

Bibliography

Pubmed IDLast YearTitleAuthors
77287591995Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.Aplan PD et al

Other Information

Locus ID:

NCBI: 6988
MIM: 600690
HGNC: 11692
Ensembl: ENSG00000145022

Variants:

dbSNP: 6988
ClinVar: 6988
TCGA: ENSG00000145022
COSMIC: TCTA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145022ENST00000273590P57738

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
195605692009T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis.7
200460132009[Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis].1
221745632012The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis.0

Citation

Jean-Loup Huret

TCTA (T-cell leukemia translocation-associated gene)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/58/tcta-(t-cell-leukemia-translocation-associated-gene)

Historical Card

1998-01-01 TCTA (T-cell leukemia translocation-associated gene) by  Jean-Loup Huret 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France