| Written | 2008-12 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France | ||
| Updated | 2009-09 | Sang-Guk Lee, Tae Sung Park, Jong Rak Choi |
| Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (SGL); Department of Laboratory Medicine, Kyung Hee University College of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea (TSP); Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (JRC) |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
| ICD-Morpho | 9920/3 Therapy-related myeloid neoplasms |
| ICD-Morpho | 9989/3 Myelodysplastic syndrome, unclassifiable |
| Atlas_Id | 1531 |
 | |
| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) |
| Epidemiology | Only 3 cases to date, a 24-year-old female patient with a M2-AML, a patient with a treatment related AML (t-AML), and a 48-year-old patient with MDS ((Koo et al., 1998; Olney et al., 2002; Park et al., 2009). Although it is a rare chromosomal abnormality, it may be an aberration related to myeloid neoplasms including AML and MDS. |
| Prognosis | No detailed data available. However, one of them (Park et al., 2009) received bone marrow transplantation; complete donor chimerism was maintained for thirteen months until last follow up. |
| Cytogenetics |
| Cytogenetics Morphological | It shows balanced chromosomal translocation between 1q21 and 12q24. |
| Additional anomalies | The patient with a M2-AML also had an i(17q). The patient with a MDS had +8, +der(12)t(1;12) additionally. |
| Genes involved and Proteins |
| Note | The genes involved in this anomaly are unknown. |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Cytogenetic and fluorescence in situ hybridization analyses of hematologic malignancies in Korea. |
| Koo SH, Kwon GC, Chun HJ, Park JW. |
| Cancer Genet Cytogenet. 1998 Feb;101(1):1-6. |
| PMID 9460492 |
| Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop. |
| Olney HJ, Mitelman F, Johansson B, Mrozek K, Berger R, Rowley JD. |
| Genes Chromosomes Cancer. 2002 Apr;33(4):413-23. |
| PMID 11921275 |
| A novel t(1;12)(q21;q24) in a patient with myelodysplastic syndrome. |
| Park TS, Lee SG, Song J, Kim JS, Choi JR. |
| Ann Hematol 2009 Aug 21. [Epub ahead of print]. |
| PMID 19697027 |
| Citation |
| This paper should be referenced as such : |
| Lee, SG ; Park, TS ; Choi, JR |
| t(1;12)(q21;q24) - update |
| Atlas Genet Cytogenet Oncol Haematol. 2010;14(8):795-796. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0112q21q24ID1531.html |
| History of this paper: |
| Huret, JL. t(1;12)(q21;q24). Atlas Genet Cytogenet Oncol Haematol. 2009;13(11):880-880. |
| http://documents.irevues.inist.fr/bitstream/handle/2042/44621/12-2008-t0112q21q24ID1531.pdf |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(1;12)(q21;q24) | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Nov 13 22:13:24 CET 2019 |
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