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t(1;12)(q21;q24)

Written2008-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Updated2009-09Sang-Guk Lee, Tae Sung Park, Jong Rak Choi
Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (SGL); Department of Laboratory Medicine, Kyung Hee University College of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea (TSP); Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea (JRC)

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1531
 

Clinics and Pathology

Disease Acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS)
Epidemiology Only 3 cases to date, a 24-year-old female patient with a M2-AML, a patient with a treatment related AML (t-AML), and a 48-year-old patient with MDS ((Koo et al., 1998; Olney et al., 2002; Park et al., 2009). Although it is a rare chromosomal abnormality, it may be an aberration related to myeloid neoplasms including AML and MDS.
Prognosis No detailed data available. However, one of them (Park et al., 2009) received bone marrow transplantation; complete donor chimerism was maintained for thirteen months until last follow up.

Cytogenetics

Cytogenetics Morphological It shows balanced chromosomal translocation between 1q21 and 12q24.
Additional anomalies The patient with a M2-AML also had an i(17q). The patient with a MDS had +8, +der(12)t(1;12) additionally.

Genes involved and Proteins

Note The genes involved in this anomaly are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Cytogenetic and fluorescence in situ hybridization analyses of hematologic malignancies in Korea.
Koo SH, Kwon GC, Chun HJ, Park JW.
Cancer Genet Cytogenet. 1998 Feb;101(1):1-6.
PMID 9460492
 
Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.
Olney HJ, Mitelman F, Johansson B, Mrozek K, Berger R, Rowley JD.
Genes Chromosomes Cancer. 2002 Apr;33(4):413-23.
PMID 11921275
 
A novel t(1;12)(q21;q24) in a patient with myelodysplastic syndrome.
Park TS, Lee SG, Song J, Kim JS, Choi JR.
Ann Hematol 2009 Aug 21. [Epub ahead of print].
PMID 19697027
 

Citation

This paper should be referenced as such :
Lee, SG ; Park, TS ; Choi, JR
t(1;12)(q21;q24) - update
Atlas Genet Cytogenet Oncol Haematol. 2010;14(8):795-796.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0112q21q24ID1531.html
History of this paper:
Huret, JL. t(1;12)(q21;q24). Atlas Genet Cytogenet Oncol Haematol. 2009;13(11):880-880.
http://documents.irevues.inist.fr/bitstream/handle/2042/44621/12-2008-t0112q21q24ID1531.pdf


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;12)(q21;q24)

External links

Mitelman databaset(1;12)(q21;q24) [Case List]    t(1;12)(q21;q24) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9920/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(1;12)(q21;q24)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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