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t(2;12)(q31;p13) ETV6/?

Written2006-11Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1459
 
  t(2;12)(q31;p13) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Clinics and Pathology

Disease Non Hodgkin lymphoma (NHL) and myelodysplastic syndrome (chronic myelomonocytic leukemia (CMML)
Epidemiology Only 2 cases to date (male patients): 1 NHL aged 30 yrs and 1 CMML aged 78 yrs
Prognosis The CMML case died 2 yrs 9 mths after diagnosis

Cytogenetics

Additional anomalies del(11q) in the NHL case and +21 in the CMML case

Genes involved and Proteins

Note ETV6 was found involved in the NHL case

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.
Case Report Reciprocal translocation t(2;12)(q31;p13) in a case of CMML

Bibliography

Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half.
Sato Y, Bohlander SK, Kobayashi H, Reshmi S, Suto Y, Davis EM, Espinosa R, Hoopes R, Montgomery KT, Kucherlapati RS, Le Beau MM, Rowley JD
Blood. 1997 ; 90 (12) : 4886-4893.
PMID 9389705
 

Citation

This paper should be referenced as such :
Huret, JL
t(2;12)(q31;p13)
Atlas Genet Cytogenet Oncol Haematol. 2007;11(2):134-134.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0212q31p13ID1459.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;12)(q31;p13) ETV6/?

External links

Mitelman databaset(2;12)(q31;p13) [Case List]    t(2;12)(q31;p13) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(2;12)(q31;p13) ETV6/?
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Sep 18 17:19:15 CEST 2017


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jlhuret@AtlasGeneticsOncology.org.