| Clinics and Pathology |
| Disease | treatment related acute non lymphoblastic leukemia (t-ANLL) |
| Phenotype / cell stem origin | M5b ANLL |
| Epidemiology | only one case; a female patient aged 23 yrs and treated 9 years ago for T-ALL |
| Prognosis | unknown; likely to be poor, both as it carries a MLL rearrangements and as occurs in t-ANLL |
| Cytogenetics |
| Cytogenetics Morphological | sole anormaly |
| Genes involved and Proteins |
| Gene Name | MLL |
| Location | in 11q23 |
| Dna / Rna | 13-15 kb mRNA |
| Protein | 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Gene Name | AF3p21 |
| Location | 3p21 |
| Result of the chromosomal anomaly |
| Description | breakpoints of MLL between exons 9 and 10 and upstream of exon 1 of the AF3p21 gene |
| Description | AT hooks and methyltransferase domains of MLL in the N-term fused to the proline-rich domain and nuclear localization signal of AF3p21 |
| External links |
| Other database | t(3;11)(p21;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(3;11)(p21;q23) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| A novel sh3 protein encoded by the AF3p21 gene is fused to MLL in a therapy-related leukemia with t(3; 11)(p21;q23). |
| Sano K, Hayakawa A, JinHua P |
| Blood. 1999 ; 94 (numero Suppl 1). |
| Contributor(s) |
| Written | 02-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(3;11)(p21;q23). Atlas Genet Cytogenet Oncol Haematol. February 2000 . URL : http://AtlasGeneticsOncology.org/Genes/t0311ID1165.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Aug 11 21:19:59 2008 |
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