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t(7;8)(p12;q24) ::MYC

Written2013-10Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

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Atlas_Id 2140

Clinics and Pathology

Disease Diffuse large B-cell lymphoma (DLBCL)
Epidemiology One case to date, a female patient aged 80 years (Bertrand et al., 2007).
Prognosis The patient died 6 months after diagnosis.


Cytogenetics Morphological A complex karyotype was found, with an i(6)(p10), a +20, and other abnormalities.

Genes involved and Proteins

Note Breakpoints occurred close to MYC in 8q24 and 100 kb from COBL and 1Mb from IKZF1 in 7p12.
- COBL is an actin nucleator which uses its WH2 domains for binding actin, to promote actin filament formation. Role in neuromorphogenesis (dendrite formation and dendritic arborisation) (Schwintzer et al., 2011).
- IKZF1 is a zinc finger transcription factor involved in both activation and repression of target genes. IKZF1 is expressed during early embryonic hematopoiesis, including hematopoietic stem cells, lymphoid precursors, erythroid precursors, and myeloid precursors. It is also expressed in developing striatal neurons. In the adult, IKZF1 expression is mainly restricted to lymphopoietic tissues and peripheral blood leukocytes (review in John and Ward, 2011).
Gene NameMYC v-myc myelocytomatosis viral oncogene homolog (avian)
Location 8q24.21
Protein DNA binding protein. Binds DNA as a heterodimer with MAX. Involved in various cellular processes including cell growth, proliferation, cell adhesion, apoptosis, angiogenesis, and stem cell behaviour modulation.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas.
Bertrand P, Bastard C, Maingonnat C, Jardin F, Maisonneuve C, Courel MN, Ruminy P, Picquenot JM, Tilly H.
Leukemia. 2007 Mar;21(3):515-23. Epub 2007 Jan 18.
PMID 17230227
The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity.
John LB, Ward AC.
Mol Immunol. 2011 May;48(9-10):1272-8. doi: 10.1016/j.molimm.2011.03.006. Epub 2011 Apr 7. (REVIEW)
PMID 21477865
The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I.
Schwintzer L, Koch N, Ahuja R, Grimm J, Kessels MM, Qualmann B.
EMBO J. 2011 Jul 1;30(15):3147-59. doi: 10.1038/emboj.2011.207.
PMID 21725280


This paper should be referenced as such :
Huret, JL
t(7;8)(p12;q24) /MYC
Atlas Genet Cytogenet Oncol Haematol. 2014;18(5):358-358.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)

 t(7;8)(p12;q24) /MYC

External links

Mitelman databaset(7;8)(p12;q24)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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