MAX (MYC associated factor X)

2003-02-01  

Identity

HGNC
LOCATION
14q23.3
LOCUSID
ALIAS
bHLHd4
FUSION GENES

Other Information

Locus ID:

NCBI: 4149
MIM: 154950
HGNC: 6913
Ensembl: ENSG00000125952

Variants:

dbSNP: 4149
ClinVar: 4149
TCGA: ENSG00000125952
COSMIC: MAX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125952ENST00000246163P61244
ENSG00000125952ENST00000284165P61244
ENSG00000125952ENST00000341653P61244
ENSG00000125952ENST00000358402P61244
ENSG00000125952ENST00000358664P61244
ENSG00000125952ENST00000394606P61244
ENSG00000125952ENST00000394606A0A024R682
ENSG00000125952ENST00000553928P61244
ENSG00000125952ENST00000553928A0A024R682
ENSG00000125952ENST00000555419G3V5L1
ENSG00000125952ENST00000555667Q6V3B1
ENSG00000125952ENST00000555932G3V2N4
ENSG00000125952ENST00000556443G3V2R5
ENSG00000125952ENST00000556892G3V570
ENSG00000125952ENST00000556979P61244
ENSG00000125952ENST00000556979A0A024R682
ENSG00000125952ENST00000557277G3V302
ENSG00000125952ENST00000557746G3V563
ENSG00000125952ENST00000618858P61244
ENSG00000125952ENST00000618858A0A024R682
ENSG00000125952ENST00000651648A0A494C130

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Small cell lung cancerKEGGko05222
MAPK signaling pathwayKEGGhsa04010
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380374902024NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X.1
381416072024A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.1
380374902024NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X.1
381416072024A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.1
368023052023MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration.3
371043682023Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma.1
368023052023MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration.3
371043682023Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma.1
351465592022MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.5
359389162022Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours.2
360613552022miR-22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC-Associated Factor X.3
364848392022Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.1
351465592022MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.5
359389162022Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours.2
360613552022miR-22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC-Associated Factor X.3

Citation

Dessen P

MAX (MYC associated factor X)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/215/max-(myc-associated-factor-x)