Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(8;12)(q22;q13) HMGA2/?

Written2005-05Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1389

Clinics and Pathology

Disease myeloproliferative/myelodysplastic syndrome (MPD/MDS)
Epidemiology only 1 case to date: a 53yr old female patient with atypical chronic myelogenous leukemia (aCML) (with no BCR-ABL rearrangement)
Cytogenetics sole anomaly in a subclone; accompanied with del(13q) in another one

Genes involved and Proteins

Gene Name HMGA2
Location 12q15
Protein probable role in regulation of cell proliferation (transcriptional regulation of cell cycle and DNA repair genes

Result of the chromosomal anomaly

Fusion Protein
Description ectopic expression of HMGA2
  

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.
Odero MD, Grand FH, Iqbal S, Ross F, Roman JP, Vizmanos JL, Andrieux J, Laï JL, Calasanz MJ, Cross NC
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (2) : 245-252.
PMID 15618963
 

Citation

This paper should be referenced as such :
Huret, JL
t(8;12)(q22;q13)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):251-251.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0812q22q13ID1389.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(8;12)(q22;q13) HMGA2/?

External links

Mitelman databaset(8;12)(q22;q13) [Case List]    t(8;12)(q22;q13) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9975/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(8;12)(q22;q13) HMGA2/?
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 30 11:23:27 CEST 2017


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.