HMGA2, the High Mobility Group A2 gene, is a non-histone and architectural transcription factor. As an oncofetal protein, HMGA2 plays an important role in development and contributes to the tumorigenesis of many epithelial and mesenchymal tumors. Upregulation of HMGA2 by non-random chromosomal translocations is common in mesenchymal tumors, whereas by the altered transcription regulation is likely the major mechanism in malignant epithelial tumors and it involves much more complex mechanisms. HMGA2 directly and indirectly regulates the multiple biological and oncogenic pathways. Its oncogenic property remains to be fully characterized.
NCBI: 8091 MIM: 600698 HGNC: 5009 Ensembl: ENSG00000149948
dbSNP: 8091 ClinVar: 8091 TCGA: ENSG00000149948 COSMIC: HMGA2
Jian-Jun Wei
HMGA2 (high mobility group AT-hook 2)
Atlas Genet Cytogenet Oncol Haematol. 2015-10-01
Online version: http://atlasgeneticsoncology.org/gene/82/hmga2-(high-mobility-group-at-hook-2)
2005-12-01 HMGA2 (high mobility group AT-hook 2) by Karin Broberg  Affiliation
2000-05-01 HMGA2 (high mobility group AT-hook 2) by Florence Pedeutour  Affiliation