LHFP (lipoma HMGIC fusion partner)
2005-01-01 Marleen Petit AffiliationLaboratory for Molecular Oncology, Department of Human Genetics, University of Leuven (K.U.Leuven) & VIB, Herestraat 49, B-3000 Leuven, Belgium
DNA/RNA
Description
Exon-intron structure not described.
Transcription
mRNA: ubiquitously: 2.4 kb; The ATG start codon is immediately preceded by an in-frame stop codon, and matches the most important positions of the Kozak consensus sequence; the 3-UTR contains a CA-repeat.
Pseudogene
No pseudogenes according to pseudogene.org.
Proteins
200 amino acids.
Description
Database searches with the predicted LHFP amino acid sequences revealed no significant similarity to any known gene or protein or any known protein motif.
Expression
Not known.
Localisation
Not known.
Function
Not known.
Homology
LHFP is a member of a family of proteins, which contains 6 members: LHFP, LHFPL1, LHFPL2, LHFPL3, LHFPL4, LHFPL5.
Mutations
Somatic
HMGA2/LHFP fusion gene encoding the three DNA-binding domains of HMGA2 followed by 69 amino acids encoded by frame-shifted LHFP sequences.
Implicated in
Entity name
Solitary lipomas.
Disease
Benign tumors of adipose tissue
Prognosis
Can be surgically removed with no recurrence in most cases.
Cytogenetics
More than 60% of solitary lipomas have an aberrant karyotype: 2/3 of these carry 12q15 rearrangements, most often translocations, affecting the HMGA2 gene:
1/4 of the latter have chromosomal region 3q27-q28 (containing LPP) as 12q15 translocation partner (creating a HMGA2/LPP fusion gene).
In the 3/4 others, multiple chromosomes have been found as translocation partner of 12q15, one of these being chromosomal region 13q12 (containing, amongst others, the LHFP gene).
Hybrid gene
HMGA2/LHFP hybrid gene containing the first three exons of HMGA2, which are followed by exon(s) of LHFP; under the regulation of the HMGA2 promoter.
Fusion protein
No known LHFP fusion protein. (HMGA2/LHFP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by 69 amino acids encoded by frame-shifted LHFP sequences).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12494468 | 2003 | Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. | Dahlén A et al |
| 10329012 | 1999 | LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. | Petit MM et al |
| 11890997 | 2002 | Absence of HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13 through 15 and 13q12 through q14. | Rogalla P et al |
Citation
Marleen Petit
LHFP (lipoma HMGIC fusion partner)
Atlas Genet Cytogenet Oncol Haematol. 2005-01-01
Online version: http://atlasgeneticsoncology.org/gene/248/lhfp-(lipoma-hmgic-fusion-partner)
