ZEB1 (zinc finger E-box binding homeobox 1)

2007-02-01  

Identity

HGNC
ZEB1
LOCATION
10p11.22
LOCUSID
6935
ALIAS
AREB6,BZP,DELTAEF1,FECD6,NIL2A,PPCD3,TCF8,ZFHEP,ZFHX1A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6935
MIM: 189909
HGNC: 11642
Ensembl: ENSG00000148516

Variants:

dbSNP: 6935
ClinVar: 6935
TCGA: ENSG00000148516
COSMIC: ZEB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148516ENST00000320985P37275
ENSG00000148516ENST00000361642P37275
ENSG00000148516ENST00000424869F6TDF5
ENSG00000148516ENST00000437844F6U0D0
ENSG00000148516ENST00000446923P37275
ENSG00000148516ENST00000542815P37275
ENSG00000148516ENST00000558440H0YND9
ENSG00000148516ENST00000559476H0YMN2
ENSG00000148516ENST00000560721P37275
ENSG00000148516ENST00000561212H0YMD3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA62ATP1A1GenePathwayassociated23788015

References

Pubmed IDYearTitleCitations
183763962008The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.1525
184834862008A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells.686
199356492009The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.660
184112772008The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.658
188295402008A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.446
195842962009Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.323
191536692009E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer.296
238276752013Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity.292
174860632007The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.254
253480032014Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.244

Citation

Dessen P

ZEB1 (zinc finger E-box binding homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46166/zeb1-(zinc-finger-e-box-binding-homeobox-1)