AGO2 (argonaute RISC catalytic component 2)

2009-01-01 Affiliation

Identity

HGNC

AGO2

LOCATION

8q24.3

LOCUSID

27161

ALIAS

CASC7,EIF2C2,LESKRES,LINC00980,PPD,Q10

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27161
MIM: 606229
HGNC: 3263
Ensembl: ENSG00000123908

Variants:

dbSNP: 27161
ClinVar: 27161
TCGA: ENSG00000123908
COSMIC: AGO2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000123908	ENST00000220592	Q9UKV8
ENSG00000123908	ENST00000519980	Q9UKV8
ENSG00000123908	ENST00000523609	E5RGG9
ENSG00000123908	ENST00000524328	E5RJY2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GAB1 signalosome	REACTOME	R-HSA-180292
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Signaling by NOTCH	REACTOME	R-HSA-157118
Pre-NOTCH Expression and Processing	REACTOME	R-HSA-1912422
Pre-NOTCH Transcription and Translation	REACTOME	R-HSA-1912408
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Gene Silencing by RNA	REACTOME	R-HSA-211000
MicroRNA (miRNA) biogenesis	REACTOME	R-HSA-203927
Small interfering RNA (siRNA) biogenesis	REACTOME	R-HSA-426486
Post-transcriptional silencing by small RNAs	REACTOME	R-HSA-426496
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21383194	2011	Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.	1056
15284456	2004	Argonaute2 is the catalytic engine of mammalian RNAi.	936
19536157	2009	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.	802
15800637	2005	Purified Argonaute2 and an siRNA form recombinant human RISC.	276
21964070	2011	miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA.	270
17382880	2007	AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.	237
22539551	2012	The crystal structure of human Argonaute2.	224
20505670	2010	Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.	217
15908945	2005	Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.	216
20699384	2010	Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.	187

Citation

Dessen P

AGO2 (argonaute RISC catalytic component 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50645/ago2-(argonaute-risc-catalytic-component-2)