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Written2009-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

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ICD-Morpho 9975/3 Chronic myelogenous leukaemia, BCR-ABL1 positive; Myeloproliferative neoplasm, unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable
Atlas_Id 1403

Clinics and Pathology

Disease Chronic myelogenous leukaemia in transformation
Epidemiology Two cases available, a male patient and a female patient aged 50 years, with a 14 months survival (Swolin et al., 1983; Mashal et al., 1990).


Cytogenetics Morphological In each of the two cases, the t(8;17) accompanied the t(9;22)(q34;q11) translocation, or a variant. No other anomaly.

Genes involved and Proteins

Note The genes involved in the t(8;17) are unknown.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia.
Mashal R, Shtalrid M, Talpaz M, Kantarjian H, Smith L, Beran M, Cork A, Trujillo J, Gutterman J, Deisseroth A.
Blood. 1990 Jan 1;75(1):180-9.
PMID 1967214
Cytogenetic studies of bone marrow and extramedullary tissues and clinical course during metamorphosis of chronic myelocytic leukemia.
Swolin B, Weinfeld A, Waldenstrom J, Westin J.
Cancer Genet Cytogenet. 1983 Jul;9(3):197-209.
PMID 6574810


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2009;13(12):980-980.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Translocations implicated (Data extracted from papers in the Atlas)


External links

Mitelman databaset(8;17)(q13;q23) [Case List]    t(8;17)(q13;q23) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9975/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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