| Written | 2007-12 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9920/3 Therapy-related myeloid neoplasms |
| Atlas_Id | 1304 |
| Clinics and Pathology |
| Disease | Treatment related acute myeloid leukaemia (t-AML) |
| Phenotype / cell stem origin | Only 2 cases to date, a M4-AML and a case with no data |
| Clinics | A 7 year old boy presented with M4-AML 67 months after treatment of a T-ALL with epipodophyllotoxins |
| Prognosis | No data |
| Genetics |
| It is likely that RUNX1 was involved in the translocation. RUNX1, also called AML1 or CBFA2, is a transcription factor, critical regulator of hematopoietic-cell development, involved in many de novo and treatment related leukaemias. |
| Cytogenetics |
| Additional anomalies | The patient also had a t(11;19)(q23;p13) and a complex karyotype with other (non-recurrent) anomalies |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. |
| Pui CH, Ribeiro RC, Hancock ML, Rivera GK, Evans WE, Raimondi SC, Head DR, Behm FG, Mahmoud MH, Sandlund JT |
| The New England journal of medicine. 1991 ; 325 (24) : 1682-1687. |
| PMID 1944468 |
| 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop. |
| Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 379-394. |
| PMID 11921272 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| t(9;21)(p22;q22) |
| Atlas Genet Cytogenet Oncol Haematol. 2009;13(1):83-83. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t0921p22q22ID1304.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(9;21)(p22;q22) | |
| External links |
| Mitelman database | t(9;21)(p22;q22) [Case List] t(9;21)(p22;q22) [Transloc-MCList] |
| arrayMap (UZH-SIB Zurich) | Topo ( C42) Morph ( 9920/3) - [auto + random 100 samples .. if exist ] [tabulated segments] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Nov 6 14:03:37 CET 2018 |
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