| Clinics and Pathology |
| Disease | Treatment related acute myeloid leukaemia (t-AML) |
| Phenotype / cell stem origin | Only 2 cases to date, a M4-AML and a case with no data |
| Clinics | A 7 year old boy presented with M4-AML 67 months after treatment of a T-ALL with epipodophyllotoxins |
| Prognosis | No data |
| Genetics |
| It is likely that RUNX1 was involved in the translocation. RUNX1, also called AML1 or CBFA2, is a transcription factor, critical regulator of hematopoietic-cell development, involved in many de novo and treatment related leukaemias. |
| Cytogenetics |
| Additional anomalies | The patient also had a t(11;19)(q23;p13) and a complex karyotype with other (non-recurrent) anomalies |
| External links |
| Other database | t(9;21)(p22;q22) | Mitelman database (CGAP - NCBI) | |
| Other database | t(9;21)(p22;q22) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. |
| Pui CH, Ribeiro RC, Hancock ML, Rivera GK, Evans WE, Raimondi SC, Head DR, Behm FG, Mahmoud MH, Sandlund JT |
| The New England journal of medicine. 1991 ; 325 (24) : 1682-1687. |
| PMID 1944468 |
| 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop. |
| Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R |
| Genes, chromosomes & cancer. 2002 ; 33 (4) : 379-394. |
| PMID 11921272 |
| Contributor(s) |
| Written | 12-2007 | Jean-Loup Huret |
| Jean Loup HURET, Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(9;21)(p22;q22). Atlas Genet Cytogenet Oncol Haematol. December 2007 . URL : http://AtlasGeneticsOncology.org/Anomalies/t0921p22q22ID1304.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:47 2008 |
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