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t(9;21)(p22;q22)

Written2007-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1304

Clinics and Pathology

Disease Treatment related acute myeloid leukaemia (t-AML)
Phenotype / cell stem origin Only 2 cases to date, a M4-AML and a case with no data
Clinics A 7 year old boy presented with M4-AML 67 months after treatment of a T-ALL with epipodophyllotoxins
Prognosis No data

Genetics

It is likely that RUNX1 was involved in the translocation. RUNX1, also called AML1 or CBFA2, is a transcription factor, critical regulator of hematopoietic-cell development, involved in many de novo and treatment related leukaemias.

Cytogenetics

Additional anomalies The patient also had a t(11;19)(q23;p13) and a complex karyotype with other (non-recurrent) anomalies

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia.
Pui CH, Ribeiro RC, Hancock ML, Rivera GK, Evans WE, Raimondi SC, Head DR, Behm FG, Mahmoud MH, Sandlund JT
The New England journal of medicine. 1991 ; 325 (24) : 1682-1687.
PMID 1944468
 
21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop.
Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R
Genes, chromosomes & cancer. 2002 ; 33 (4) : 379-394.
PMID 11921272
 

Citation

This paper should be referenced as such :
Huret, JL
t(9;21)(p22;q22)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(1):83-83.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t0921p22q22ID1304.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(9;21)(p22;q22)

External links

Mitelman databaset(9;21)(p22;q22) [Case List]    t(9;21)(p22;q22) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9920/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(9;21)(p22;q22)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Sep 18 17:19:55 CEST 2017


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