t(9;21)(p22;q22)
2007-12-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Treatment related acute myeloid leukaemia (t-AML)
Phenotype stem cell origin
Only 2 cases to date, a M4-AML and a case with no data
Clinics
A 7 year old boy presented with M4-AML 67 months after treatment of a T-ALL with epipodophyllotoxins
Prognosis
No data
Note
It is likely that RUNX1 was involved in the translocation. RUNX1, also called AML1 or CBFA2, is a transcription factor, critical regulator of hematopoietic-cell development, involved in many de novo and treatment related leukaemias.
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 1944468 | 1991 | Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. | Pui CH et al |
| 11921272 | 2002 | 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop. | Slovak ML et al |
Citation
Jean-Loup Huret
t(9;21)(p22;q22)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/haematological/1304/t(9;21)(p22;q22)
