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t(11;12)(p15;q13) NUP98/?

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1185
 
  t(11;12)(p15;q13) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Clinics and Pathology

Disease treatment related acute myeloid leukemia (t-AML) so far
Epidemiology only one case; a female patient aged 39 yrs and treated with antitopoisomerase II for Hodgkin disease

Cytogenetics

Cytogenetics Morphological showed also a t(17;21)(q11;q22) with AML1 rearrangement

Genes involved and Proteins

Note the gene involved in 12q13 is unknown
Gene Name NUP98
Location 11p15
Dna / Rna alternate splicings
Protein contains repeated motifs and a RNA binding motif; nucleoporin: role in nucleo-cytoplasmic transport

Result of the chromosomal anomaly

Hybrid gene
Description 5 prime NUP98 - 3 prime unknown
  
Fusion Protein
Description fuses the N-term domains of NUP98 to an undetermined sequence
  

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

NUP98 gene rearrangements in leukemia detected by fluorescence in situ hybridization (FISH).
Kobzev YN, Rowley JD
Blood. 1999 ; 94 (numero Suppl 1).
 
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy.
Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD
Blood. 1998 ; 92 (8) : 2879-2885.
PMID 9763573
 

Citation

This paper should be referenced as such :
Huret, JL
t(11;12)(p15;q13)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):33-34.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1112ID1185.html


Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes NUP98

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;12)(p15;q13) NUP98/?

External links

Mitelman databaset(11;12)(p15;q13) [Case List]    t(11;12)(p15;q13) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9920/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(11;12)(p15;q13) NUP98/?
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Mar 14 13:55:22 CET 2017


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jlhuret@AtlasGeneticsOncology.org.