| Clinics and Pathology |
| Disease | treatment related acute non lymphoblastic leukemia (t-ANLL) so far |
| Epidemiology | only one case; a female patient aged 39 yrs and treated with antitopoisomerase II for Hodgkin disease |
| Cytogenetics |
| Cytogenetics Morphological | showed also a t(17;21)(q11;q22) with AML1 rearrangement |
| Genes involved and Proteins |
| Note | the gene involved in 12q13 is unknown |
| Gene Name | NUP98 |
| Location | 11p15 |
| Dna / Rna | alternate splicings |
| Protein | contains repeated motifs and a RNA binding motif; nucleoporin: role in nucleo-cytoplasmic transport |
| Result of the chromosomal anomaly |
| Description | 5 prime NUP98 - 3 prime unknown |
| Description | fuses the N-term domains of NUP98 to an undetermined sequence |
| External links |
| Other database | t(11;12)(p15;q13) | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;12)(p15;q13) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy. |
| Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD |
| Blood. 1998 ; 92 (8) : 2879-2885. |
| PMID 9763573 |
| NUP98 gene rearrangements in leukemia detected by fluorescence in situ hybridization (FISH). |
| Kobzev YN, Rowley JD |
| Blood. 1999 ; 94 (numero Suppl 1). |
| Contributor(s) |
| Written | 02-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(11;12)(p15;q13). Atlas Genet Cytogenet Oncol Haematol. February 2000 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1112ID1185.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:12:55 2008 |
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