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t(12;17)(p11;q11) in AML

Written2006-11David Betts
Department of Oncology, University Children's Hospital, Steinwiesstr. 75, CH-8032 Zò_rich, Switzerland

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1437

Clinics and Pathology

Disease Acute myeloid leukaemia (AML)
Note The appearance of the translocation may resemble the rare non-random t(12;17)(p13;q11-21) associated with ALL.
Epidemiology Very rare translocation reported in three adults and one child with secondary AML following an ALL. The four published cases have been female.
Prognosis Insufficient data to indicate a prognostic significance.

Cytogenetics

Additional anomalies All reported cases have additional aberrations. In two cases the translocation is part of a complex karyotype. Three of the four cases are reported to have loss of the second chromosome 17.

Genes involved and Proteins

Note No report of any molecular or FISH data to elucidate exact breakpoint or genes.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG).
Genes, chromosomes & cancer. 1992 ; 5 (3) : 252-254.
PMID 1384679
 
Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia.
Brozek I, Babiń'ska M, Kardaś I, Woźniak A, Balcerska A, Hellmann A, Limon J
Journal of applied genetics. 2003 ; 44 (3) : 401-412.
PMID 12923315
 
Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping.
Kerndrup GB, Kjeldsen E
Cancer genetics and cytogenetics. 2001 ; 124 (1) : 7-11.
PMID 11165315
 
Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.
Sun GX, Koeffler HP, Gale RP, Sparkes RS, Schreck RR
Cancer genetics and cytogenetics. 1990 ; 46 (1) : 107-113.
PMID 2331674
 

Citation

This paper should be referenced as such :
Betts, D
t(12;17)(p11;q11) in AML
Atlas Genet Cytogenet Oncol Haematol. 2007;11(2):135-135.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1217p11q11ID1437.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(12;17)(p11;q11) in AML

External links

Mitelman databaset(12;17)(p11;q11) [Case List]    t(12;17)(p11;q11) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(12;17)(p11;q11) in AML
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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