| Clinics and Pathology |
| Disease | Acute myeloid leukaemia (AML) |
| Note | The appearance of the translocation may resemble the rare non-random t(12;17)(p13;q11-21) associated with ALL. |
| Epidemiology | Very rare translocation reported in three adults and one child with secondary AML following an ALL. The four published cases have been female. |
| Prognosis | Insufficient data to indicate a prognostic significance. |
| Cytogenetics |
| Additional anomalies | All reported cases have additional aberrations. In two cases the translocation is part of a complex karyotype. Three of the four cases are reported to have loss of the second chromosome 17. |
| Genes involved and Proteins |
| Note | No report of any molecular or FISH data to elucidate exact breakpoint or genes. |
| External links |
| Other database | t(12;17)(p11;q11) in AML | Mitelman database (CGAP - NCBI) | |
| Other database | t(12;17)(p11;q11) in AML | CancerChromosomes (NCBI) | |
| Other database | http://cgap.nci.nih.gov/Chromosomes/Mitelman | ||
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia. |
| Sun GX, Koeffler HP, Gale RP, Sparkes RS, Schreck RR |
| Cancer genetics and cytogenetics. 1990 ; 46 (1) : 107-113. |
| PMID 2331674 |
| Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG). |
| Genes, chromosomes & cancer. 1992 ; 5 (3) : 252-254. |
| PMID 1384679 |
| Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping. |
| Kerndrup GB, Kjeldsen E |
| Cancer genetics and cytogenetics. 2001 ; 124 (1) : 7-11. |
| PMID 11165315 |
| Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia. |
| Brozek I, Babi‰Ńska M, Karda‰ő I, Wo‰†niak A, Balcerska A, Hellmann A, Limon J |
| Journal of applied genetics. 2003 ; 44 (3) : 401-412. |
| PMID 12923315 |
| Contributor(s) |
| Written | 11-2006 | David Betts |
| Citation |
| This paper should be referenced as such : |
| Betts D . t(12;17)(p11;q11) in AML. Atlas Genet Cytogenet Oncol Haematol. November 2006 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1217p11q11ID1437.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:13:08 2008 |
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