+10 or trisomy 10 (solely)
2006-05-01 Zachary T Lewis , Zachary T Lewis , Zachary T Lewis Affiliation1.Department of Pediatrics, Section on Medical Genetics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
2.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), Acute Biphenotypic Leukemia, and myelodysplastic syndromes (MDS).
Note
Classification : Approximately 33 cases with isolated Trisomy 10 have been described. Over two-thirds of cases associated with this cytogenetic abnormality are AML-M0, M1, or M2; M2 is the most common AML variant in the FAB classification (one-third of cases). Trisomy 10 has been, however, described in all of the FAB variants except M3. Over half of the AML cases have been associated with CD7 expression. Twenty-one cases of AML (including one of our own cases) have been described in the literature. One case each of biphenotypic acute leukemia and eosinophilic leukemia with trisomy 10 have been described. Two cases (including one of our own cases) of high grade MDS (i.e. refractory anemia with excess blasts-2 (RAEB-2)) have been associated with isolated trisomy 10. When specified, most cases of ALL were of the Pre-B type. There have been eight cases of ALL with +10 as the sole abnormality.
Phenotype stem cell origin
ALL cases are mostly pre B ALL; AML cases are M0, M1 or M2 AML, with, in most cases, a CD7+, CD33+ phenotype.
Epidemiology
The incidence of isolated trisomy 10 is less than 1% in acute leukemia. About sixty percent of the AML cases have been in males while the ALL cases have had a near equal male to female ratio. About half of the AML cases have been in patients of Oriental descent. AML cases have ranged in age from two to eighty years of age with a median age of fifty-four years. ALL cases with this cytogenetic abnormality are not strictly seen in the pediatric age range. Three cases (including one of our own cases) have been seen in the adult population.
Clinics
in AML cases: WBC: 20 X 109/l; high blast percentage, low haemoglobin.
Prognosis
About half of the AML cases and two-thirds of the ALL cases have had at least a one year survival after diagnosis. The average survival for AML cases has been 26 months while the ALL cases had a 19 month average survival.
Note
genes involved are unknown
Genes Involved and Proteins
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10214501 | 1999 | Are cells with trisomy 10 always malignant in hematopoietic disorders? | Berger R et al |
| 1528067 | 1992 | Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents. | Cuneo A et al |
| 11996802 | 2002 | Trisomy 10 and acute myeloid leukemia. | Czepulkowski B et al |
| 9973950 | 1999 | Trisomy 10 as a sole chromosomal abnormality in AML-M2. | Estalilla O et al |
| 1606550 | 1992 | Distinct cytogenetic and clinicopathologic features in acute myeloid leukemia after occupational exposure to pesticides and organic solvents. | Fagioli F et al |
| 1206119 | 1975 | Agar culture and chromosome analysis of eosinophilic leukaemia. | Goldman JM et al |
| 6585926 | 1984 | The relationship between growth in agar, karyotype and prognosis in acute leukaemia. | Gustavsson A et al |
| 11342322 | 2000 | Trisomy 10 as the sole abnormality in biphenotypic leukemia. | Inoue T et al |
| 10748296 | 2000 | Trisomy 10 in acute myeloid leukemia: three new cases. | Llewellyn IE et al |
| 9406587 | 1998 | Trisomy 10 in acute myeloid leukemia: report of a new case. | Luño E et al |
| 9973969 | 1999 | Trisomy 10 in acute myeloid leukemia: revisited. | Ma SK et al |
| 8697428 | 1996 | Trisomy 10: age and leukemic lineage associations. | Morgan R et al |
| 8697414 | 1996 | Trisomy 10 in acute myeloid leukemia. | Ohyashiki K et al |
| 10331517 | 1999 | Trisomy 10 in adult pre-B-cell leukemia. | Okamura A et al |
| 9614911 | 1998 | Trisomy 10 survival: a literature review and presentation of seven new cases. | Pedersen B et al |
| 1596566 | 1992 | Hyperdiploid (47-50) acute lymphoblastic leukemia in children. | Raimondi SC et al |
| 7504523 | 1993 | In situ hybridization to interphase nuclei in acute leukemia. | Romana SP et al |
| 10565299 | 1999 | Trisomy 10 in a child with acute nonlymphocytic leukemia followed by relapse with a different clone. | Sakai Y et al |
| 10942805 | 2000 | Trisomy 10 in acute myeloid leukemia. Three additional cases from the database of the Japan Adult Leukemia Study Group (JALSG) AML-92 and AML-95. | Suzuki A et al |
| 1695699 | 1990 | A subset of acute nonlymphocytic leukemia with expression of surface antigen CD7--morphologic, cytochemical, immunocytochemical and T cell receptor gene analysis on 13 patients. | Tien HF et al |
| 7630192 | 1995 | Clonal analysis of progenitor cells by interphase cytogenetics in patients with acute myeloid leukemia and myelodysplasia. | Van Der Lely N et al |
Citation
Zachary T Lewis ; Zachary T Lewis ; Zachary T Lewis
+10 or trisomy 10 (solely)
Atlas Genet Cytogenet Oncol Haematol. 2006-05-01
Online version: http://atlasgeneticsoncology.org/haematological/1063/+10-or-trisomy-10-(solely)
Historical Card
1998-08-01 +10 or trisomy 10 (solely) by Jean-Loup Huret Affiliation
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
