Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

+15 or trisomy 15 (as sole autosomal abnormality)

Written1999-05Elizabeth J Sinclair, Anthony M Potter
Centre for Human Genetics, Sheffield, United Kingdom

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1144

Clinics and Pathology

Disease myeloid and lymphoid lineages (myelodysplastic syndromes (MDS), acute nonlymphocytic leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic lymphocytic leukaemia (CLL)); also reported in patients free of haematological malignancy
Phenotype / cell stem origin most commonly seen in low grade MDS, usually RA
Epidemiology frequency: rare; marked male predominance; found mostly in adults; med age: 77
Prognosis not known

Cytogenetics

Additional anomalies sex chromosome aneuploidy, particularly -Y in males

Genes involved and Proteins

Note is/are not known

To be noted

proposed association between loss of Y chromosome and trisomy 15, which may reflect an underlying age effect in some cases

Bibliography

Trisomy 15 associated with loss of the Y chromosome in bone marrow: a possible new aging effect.
Sinclair EJ, Potter AM, Watmore AE, Fitchett M, Ross F
Cancer genetics and cytogenetics. 1998 ; 105 (1) : 20-23.
PMID 9689925
 
Trisomy 15 in hematological malignancies: six cases and review of the literature.
Smith SR, Rowe D
Cancer genetics and cytogenetics. 1996 ; 89 (1) : 27-30.
PMID 8689605
 

Citation

This paper should be referenced as such :
Sinclair, EJ ; Potter, AM
+15 or trisomy 15 (as sole autosomal abnormality)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):86-86.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/tri15ID1144.html


External links

arrayMapTopo ( C42) Morph ( 9811/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9861/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMapTopo ( C42) Morph ( 9989/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease database+15 or trisomy 15 (as sole autosomal abnormality)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 27 12:51:37 CET 2017


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.